Identification of Gene Biomarkers in Aging Skin
This study is a blinded, prospective, single-center, clinical study conducted in Japanese female subjects between the ages of 20-75 years. This design uses skin biopsy samples from environmentally exposed areas and unexposed (control) areas within the same subjects to assess the gene expression profile from three different age groups.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Identification of Gene Biomarkers in Aging Skin; a Blinded, Prospective, Single-center, Clinical Study|
- The primary objective of the study is to investigate changes in gene expression patterns that occur during the aging process. A significant fold change in differential gene expression will be >1.5 and an adjusted p-value of <0.05. [ Time Frame: 1 year ] [ Designated as safety issue: No ]
- Secondary outcome measures are the evaluation of genetic expression changes in sun-protected and sun-exposed skin and an investigation of their biological pathways. [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
A 4 mm punch biopsy taken from exposed and unexposed skin.
|Study Start Date:||August 2008|
|Study Completion Date:||April 2009|
|Primary Completion Date:||November 2008 (Final data collection date for primary outcome measure)|
Young age: 20 to 30 years old
Middle Age: 38 to 48 years old (pre-menopausal only)
Elderly Age: 60 to 75 years old (Post-menopausal only)
The primary objective of the skin aging study is to investigate changes in gene expression patterns that occur during the aging process.
|Thomas J. Stephens & Associates, Japan Research Center|
|1-27-2 Oji, Kita-Ku, Tokyo, Japan, 114-0002|
|Study Director:||Prakash Prabhakar, PhD||Interleukin Genetics|
|Study Director:||Karen Shaver, MS||Interleukin Genetics|