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Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of Anti-inflammatory Effects

This study is currently recruiting participants.
Verified August 2011 by University of Nebraska
Sponsor:
Information provided by:
University of Nebraska
ClinicalTrials.gov Identifier:
NCT00874757
First received: April 1, 2009
Last updated: August 2, 2011
Last verified: August 2011
History of Changes
  Purpose

The purpose of this study is to see whether Statin drugs will act as anti-inflammatories. The investigators will study this potential anti-inflammatory activity in healthy subjects.


Condition
Healthy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of

Resource links provided by NLM:

MedlinePlus related topics: Statins
U.S. FDA Resources

Further study details as provided by University of Nebraska:

Estimated Enrollment: 20
Study Start Date: July 2009
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   19 Years to 39 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

20 healthy subjects

Criteria

Inclusion Criteria:

  • Healthy male non-asian subjects

Exclusion Criteria:

  • Patients with increased liver function tests, elevated serum creatinine, patients on anti-inflammatory or immunomodulating drugs
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00874757

Contacts
Contact: Timothy R McGuire, Pharm.D. 402-559-8224 trmcguir@unmc.edu
Contact: Paul Dobesh, Pharm.D. 402-559-1983 pdobesh@unmc.edu

Locations
United States, Nebraska
UNMC College of Pharmacy Recruiting
Omaha, Nebraska, United States, 68198-6045
Contact: Timothy R McGuire, Pharm.D.     402-559-8224     trmcguir@unmc.edu    
Contact: Paul Dobesh, Pharm.D.     402-559-1983     pdobesh@unmc.edu    
Sponsors and Collaborators
University of Nebraska
Investigators
Principal Investigator: Timothy R McGuire, PharmD University of Nebraska
  More Information

No publications provided

Responsible Party: Timothy R. McGuire, University of Nebraska College of Pharmacy
ClinicalTrials.gov Identifier: NCT00874757     History of Changes
Other Study ID Numbers: 088-09
Study First Received: April 1, 2009
Last Updated: August 2, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by University of Nebraska:
Statins, anti-inflammatory
Healthy subjects study

Additional relevant MeSH terms:
Anti-Inflammatory Agents
Rosuvastatin
Therapeutic Uses
Pharmacologic Actions
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anticholesteremic Agents
 Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Enzyme Inhibitors
Lipid Regulating Agents

ClinicalTrials.gov processed this record on May 22, 2013