High Frequency Chest Wall Oscillation in Chronic Obstructive Pulmonary Disease (COPD)
Patients with Chronic obstructive pulmonary disease (COPD) tend to have cough, excess mucus production and breathlessness as cardinal features. The excess mucus production often leads to frequent infections, exacerbations and poor quality of life. Mucociliary clearance may have an impact on improving symptoms, exercise tolerance, quality of life and reduce exacerbations.
High frequency chest wall oscillation(HFCWO) devices use percussion to the chest wall delivered from a pump through a close fitting inflatable vest. This technique has been shown to enhance mucus clearance in patients with cystic fibrosis and Bronchiectasis. This pilot study was designed to explore the feasibility, tolerance and effectiveness of the HFCWO in patients with advanced COPD.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Self-Administered High Frequency Chest Wall Oscillation Technique for Mucus Clearance in COPD: An Exploratory Pilot Project Using the SMARTVEST Device|
- Health related quality of life (St George's Respiratory Questionnaire) [ Time Frame: 3 months ] [ Designated as safety issue: No ]
- Exercise tolerance (Endurance Shuttle Walk Time achieved) [ Time Frame: 3 months ] [ Designated as safety issue: No ]
|Study Start Date:||August 2006|
|Study Completion Date:||October 2007|
|Primary Completion Date:||October 2007 (Final data collection date for primary outcome measure)|
HFCWO twice a day delivered by SmartVest device at 13Hz FOR 20min x2. Duration 4 weeks in each phase with a 2week washout.
Device: HFCWO - SmartVest
SmartVest with vest administered for 20min at 11-13Hz
Other Name: SmartVest
No Intervention: Placebo/Control
Self-administered breathing exercises
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|East & North Herts NHS Trust|
|Stevenage, Herts, United Kingdom, SG1 4AB|
|Principal Investigator:||Indranil Chakravorty, PhD, MRCP||East & North Herts NHS Trust, Stevenage, Herts, UK|