An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy
The overall goal of this project is to better understand the micro-physiology of human epilepsy and cognition using the intracranial electroencephalogram (iEEG), Stimulation Mapping, and functional magnetic resonance imaging (fMRI).
Other: Releasing Data
Other: Neuropsychological Testing
Other: Additional electrode implantation
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy Using Electrophysiology, Cortical Mapping, and fMRI|
- epilepsy surgical outcome [ Time Frame: 1 year minimum ] [ Designated as safety issue: No ]We are primarily interested in finding ways of predicting the effects of epilepsy surgery on seizure control and cognitive function.
|Study Start Date:||November 2007|
|Estimated Study Completion Date:||June 2015|
|Estimated Primary Completion Date:||June 2015 (Final data collection date for primary outcome measure)|
The overall goal of this project is to better understand the micro-physiology of human epilepsy and cognition using iEEG, Stimulation Mapping, and fMRI.
Specific AIM 1: Identifying laminar activity during seizures using intracranial electrodes. This will help to better characterize the neuronal path of ictal activity in the human brain. Exploring the relationship of intracranial electroencephalographic recordings and stimulation mapping will allow us to study the organization of seizure propagation in the cortex. The use of laminar probes should enable us to explore the organization of networks that underlie seizure generation and propagation as may be revealed by recording from different layers of the cortex.
Specific AIM 2: Elucidating cognitive networks using intracranial electrodes. We will be investigating the functional connectivity of cognitive networks and information processing in the brain. Multiple aspects of language processing including word generation, auditory comprehension, and naming will be studied in order to help build a working model of language processing in the brain. We will also explore how the brain processes human faces and the network it uses to do so. Sensory and motor processing networks will be investigated as well. The use of laminar probes will help us to determine the hierarchical organization of these processing networks.
Specific AIM 3: Identifying the relationship between fMRI, electrophysiology and stimulation mapping. We will also be studying the relationship of pre-operative fMRI and cortical stimulation mapping in order to locate critical sites in the information processing network for language. Cortical localization of these sites may assist in the guidance of neurosurgical resections of eloquent cortex. The relationship between areas highlighted by fMRI and stimulation mapping will be explored.
|United States, New York|
|Comprehensive Epilepsy Care Center|
|Great Neck, New York, United States, 11021|
|Principal Investigator:||Ashesh Mehta, M.D., Ph.D.||Hofstra North Shore LIJ School of Medicine and Feinstein Institute for Medical Research|