Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer: Concordance Study
This study will examine genes in three different tissues and look for similarities and differences between normal cells and cancer cells. The tissues to be studies come from blood, lymph node and cancer.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer: Concordance Study|
- Single nucleotide polymorphisms [ Time Frame: time-independent ] [ Designated as safety issue: No ]Determine single nucleotide polymorphism concordances between the three DNA specimen sources
Biospecimen Retention: Samples With DNA
Retained samples will consist of a portion of the specimens collected for this concordance study: peripheral blood leukocytes, lymph nodes, and tumor tissue. All retained samples will be completely de-identified and re-numbered.
|Study Start Date:||March 2009|
|Estimated Study Completion Date:||January 2015|
|Estimated Primary Completion Date:||June 2014 (Final data collection date for primary outcome measure)|
Subjects will be given an informed consent to read and sign The medical chart will be reviewed for diagnosis and treatment history Blood (about 4 tablespoons) will be drawn at a clinically available time. The lymph node and breast tumor tissue in the University of Michigan pathology repository will be used for research purposes
Please refer to this study by its ClinicalTrials.gov identifier: NCT00858585
|United States, Michigan|
|University of Michigan|
|Ann Arbor, Michigan, United States, 48109|
|Principal Investigator:||Catherine Van Poznak, MD||University of Michigan Cancer Center|