The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels (WLMBL)

This study has been completed.
Sponsor:
Collaborator:
Aarhus University Hospital
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00854412
First received: March 2, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted
  Purpose

High levels of mannose-binding lectin (MBL), an activator of a part of the immune system called the complement system, have been associated with increased mortality and risk of early signs of kidney damage in patients with type 2 diabetes. The effect of weight loss and changes in insulin resistance on MBL levels have been poorly elucidated.

This study includes 36 nondiabetic obese subjects, who will receive a very low- calorie diet (VLCD) of 800 kcal/day for 8 weeks.

Fasting blood samples will be obtained at baseline and after 8 weeks of VLCD and concentrations of MBL, glucose and insulin will be measured. Insulin resistance is assessed using the HOMA-IR method.


Condition Intervention
Obesity
Weight Loss
Other: Weight loss

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: The Effect of Weight Loss on Serum Mannose-Binding Lectin (MBL) Levels

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Enrollment: 36
Study Start Date: March 1995
Study Completion Date: June 1995
Primary Completion Date: June 1995 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: Weight loss
    Very low-calorie diet (VLCD) of 800 kcal/day for 8 weeks
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Obese

Exclusion Criteria:

  • Diabetes
  • Other severe disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Pernille Høyem MD, PhD-student, Medical Department M, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT00854412     History of Changes
Other Study ID Numbers: MBL1
Study First Received: March 2, 2009
Last Updated: March 2, 2009
Health Authority: Denmark: The Regional Committee on Biomedical Research Ethics

Keywords provided by University of Aarhus:
Obesity
Weight loss
Very low-calorie diet
Mannose-binding lectin
Insulin resistance

Additional relevant MeSH terms:
Body Weight
Obesity
Weight Loss
Body Weight Changes
Nutrition Disorders
Overnutrition
Overweight
Signs and Symptoms

ClinicalTrials.gov processed this record on October 22, 2014