Co-existent Obstructive Sleep Apnea (OSA) and Obesity: Finding Non-exercise Activity Thermogenesis (NEAT) Targets for Intervention
Rationale: Obesity is an increasing childhood epidemic in Canada. Obstructive sleep apnea (OSA) is a complication of obesity which causes cardiovascular disease, reduced quality of life, and premature death. While the complex interactions between obesity and OSA are not entirely clear, we hypothesize that these conditions may compound each other by:
- decreasing physical activity and total energy expenditure by reducing both non-exercise physical pursuits (NEAT- non-exercise activity thermogenesis) and purposeful physical activity.
- alterations in the secretion of appetite-controlling hormones, which may lead to increases in energy intake.
Objective: To determine whether the presence of both obesity and OSA in children is associated with a decrease in physical activity and alterations in appetite-regulating hormones greater than those seen in either condition alone or compared to controls.
Methods: Comparison of children 10-17 years with obesity and OSA, obesity alone, OSA alone and neither condition, for the following outcomes: (1) NEAT (kcal/day) (2) Physical activity behavior, appetite regulating hormone profile and self-report appetite assessment.
Unique Aspects: This study combines expertise in sleep medicine, exercise physiology and obesity. Conclusions from this study will better characterize this high-risk clinical population so that innovative strategies targeting improvements in lifestyle behaviors can be developed.
Childhood Obstructive Sleep Apnea
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Co-existent OSA and Obesity: Finding NEAT Targets for Intervention|
- NEAT (kcal/day) [ Time Frame: 10 day period ] [ Designated as safety issue: No ]
- Physical activity behavior (minutes of moderate-vigorous physical activity as directly measured by accelerometry), appetite regulating hormone profile and self-report appetite assessment. [ Time Frame: 10 day period ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||September 2010|
|Estimated Study Completion Date:||December 2011|
|Estimated Primary Completion Date:||September 2011 (Final data collection date for primary outcome measure)|
Children with both obesity and obstructive sleep apnea
Children without the presence of both obesity and obstructive sleep apnea
|Contact: Lynda Hoey, RN, CCRP||613-737-7600 ext firstname.lastname@example.org|
|Childrens Hospital of Eastern Ontario||Recruiting|
|Ottawa, Ontario, Canada, K1H 8L1|
|Principal Investigator: Sherri Katz|
|Principal Investigator: Rachel Colley|