Family Research Study: Metabolism of Fats and Proteins in Specific Ethnic Groups
The purpose of this study is to determine whether lipoprotein(a), also called Lp(a), is a risk factor for cardiovascular (heart) disease. Lipoproteins are tiny particles that circulate in the blood. They contain cholesterol, fat, and protein in varying amounts depending on the body's need. Higher levels of lipoproteins in the blood can cause an increased risk of heart disease.
The investigators believe that by studying the Lp(a) lipoprotein in Caucasians and African Americans, the investigators can assess for genetic variation factors related to cardiovascular (heart) disease. The investigators will be looking at 100 African-American families and 100 Caucasian families to confirm whether a higher Lp(a) level is an indicator of a higher risk for heart disease.
|Study Design:||Observational Model: Family-Based
Time Perspective: Cross-Sectional
|Official Title:||Regulation of Lipoprotein(a) Metabolism in Humans With Reference to Ethnicity|
- Genetic variation of Lp(a) levels in each group [ Time Frame: five years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
plasma, DNA, white blood cell
|Study Start Date:||February 2009|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||March 2011 (Final data collection date for primary outcome measure)|
|African American Families|
During the study visit the research staff will ask about the medical history, perform a brief physical exam, and draw approximately 4 teaspoons of blood of each family member.
|Contact: Tina Tran||916-703-9127|
|United States, California|
|UC Davis CTSC Clinical Research Center (CCRC) at Veterans Affair Medical Center||Recruiting|
|Mather, California, United States, 95655|
|Principal Investigator:||Lars Berglund, M.D., Ph.D.||University of California, Davis|