Energy Expenditure in Weaning From Mechanical Ventilation

This study has been completed.
Sponsor:
Information provided by:
Hospital de Clinicas de Porto Alegre
ClinicalTrials.gov Identifier:
NCT00853060
First received: February 25, 2009
Last updated: February 26, 2009
Last verified: February 2009
  Purpose

During weaning from mechanical ventilation process, the energy expenditure in T tube is greater than pressure support ventilation.


Condition
Respiration, Artificial
Energy Metabolism

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Energy Expenditure During Weaning From Mechanical Ventilation: Is There Any Difference Between Pressure Support and T-Tube?

Further study details as provided by Hospital de Clinicas de Porto Alegre:

Enrollment: 40
Study Start Date: March 2006
Study Completion Date: March 2008
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Detailed Description:

The energy expenditure (EE) was measured during the two periods of 30-minutes, with the 10 first minutes being discarded for analysis purposes. The other variables were recorded and monitored during the 10th and the 30th minute, in both pressure support (PS) and t-Tube (TT) modes. Patients were randomized in terms of sequence selection: PS - TT or TT - PS. In the baseline period, patients were receiving mechanical ventilation (Servo 900C and Servo 300; Siemens-Elema, Solna, Sweden), with PS ranging from 10 to 15cmH2O. During the PS mode, patients received assisted pressure ventilation of 10 cmH2O, 5 cmH2O of final positive expiratory pressure, the sensitivity of -1cmH2O and FiO2 of 0.4. During TT mode, oxygen flow was delivered in order to keep the same FiO2 that was provided in PS (0.4) as controlled by monitor screen (Datex Ohmeda S/5 - Compact Airway Module, M-COVX model, Finland). In this mode, an extensor was employed, one end of which was connected to the oxygen-enriched and the other end was secured to a 3-output ("T") connector, which was attached to the patient's ventilatory prosthesis. During the rest period (30 minutes), patients returned to the mechanical ventilation parameters utilized in the baseline period.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with respiratory failure receiving MV fore more than 24 hours, who had been admitted to the Intensive Care Unit (ICU) of the Hospital de Clínicas de Porto Alegre and who met the criteria for weaning from MV according to the parameters previously defined were selected to participate in the study.

Criteria

Inclusion Criteria:

  • Patients with acute respiratory failure receiving MV for over 24 hours, in the ICU of the Hospital de Clínicas de Porto Alegre

Exclusion Criteria:

  • Patients with chest drainage, hemodynamic instability (characterized by the use of vasoactive drugs), renal failure, mental status change, agitation, sudoresis, tachycardia, axillary temperature above 38°C and inspiratory oxygen fraction (FiO2) over 0.6.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00853060

Locations
Brazil
Federal University of Rio Grande do Sul/Hospital de Clínicas de Porto Alegre
Porto Alegre, RS, Brazil
Sponsors and Collaborators
Hospital de Clinicas de Porto Alegre
Investigators
Principal Investigator: Silvia Vieira, PhD Federal University of Rio Grande do Sul
  More Information

No publications provided

Responsible Party: Silvia Regina Rios Vieira, Hospital de Clínicas de Porto Alegre
ClinicalTrials.gov Identifier: NCT00853060     History of Changes
Other Study ID Numbers: 04-415
Study First Received: February 25, 2009
Last Updated: February 26, 2009
Health Authority: Brazil: National Committee of Ethics in Research

Keywords provided by Hospital de Clinicas de Porto Alegre:
energy expenditure
mechanical ventilation
weaning
pressure support ventilation
T-tube

ClinicalTrials.gov processed this record on July 28, 2014