Neurohumoral Control of Intestinal Electrical and Mechanical Activity

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Neal Fleming, MD, PhD, University of California, Davis
ClinicalTrials.gov Identifier:
NCT00852553
First received: February 26, 2009
Last updated: July 23, 2012
Last verified: July 2012
  Purpose

A collaborative research project with Dr. Kathleen Keef (Department of Physiology, University of Nevada School of Medicine, Reno, Nevada) studying the role of putative neurotransmitters in human intestine.


Condition
Morbid Obesity

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Neurohumoral Control of Intestinal Electrical and Mechanical Activity

Resource links provided by NLM:


Further study details as provided by University of California, Davis:

Biospecimen Retention:   Samples Without DNA

jejunum


Enrollment: 45
Study Start Date: February 2003
Study Completion Date: February 2012
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Detailed Description:

Segments of intestine from patients undergoing elective gastric bypass for morbid obesity or resections for non-obstructive neoplasms at the UC Davis Medical Center will be used. Samples will be taken from tissue normally removed and sent to Pathology or discarded. Full thickness segments of intestine (10 mm x 1 mm) will be prepared for recording either intracellular electrical activity or mechanical contraction. The effects of putative non-adrenergic, non-cholinergic neurotransmitters (e.g., nitric oxide) will be studied. The source of the tissue will not be identified either directly or indirectly through identifiers associated with the measured responses.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

All patients having elective bowel resections

Criteria

Inclusion Criteria:

  • All patients having elective bowel resection

Exclusion Criteria:

  • Entire resected segment required for pathology
  • Ischemic/necrotic disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00852553

Locations
United States, California
University of California, Davis Medical Center
Sacramento, California, United States, 95817
United States, Nevada
University of Nevada School of Medicine
Reno, Nevada, United States, 89557
Sponsors and Collaborators
University of California, Davis
Investigators
Principal Investigator: Neal W. Fleming, M.D., Ph.D. Professor
  More Information

No publications provided

Responsible Party: Neal Fleming, MD, PhD, Professor, University of California, Davis
ClinicalTrials.gov Identifier: NCT00852553     History of Changes
Other Study ID Numbers: 200311379, 200311379-8
Study First Received: February 26, 2009
Last Updated: July 23, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, Davis:
intestinal
smooth
muscle
GI
motility

Additional relevant MeSH terms:
Obesity
Obesity, Morbid
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on August 25, 2014