Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target

This study is currently recruiting participants.
Verified August 2013 by University of California, Irvine
Sponsor:
Collaborator:
Beckman Laser Institute University of California Irvine
Information provided by (Responsible Party):
Montana Compton, University of California, Irvine
ClinicalTrials.gov Identifier:
NCT00842283
First received: February 11, 2009
Last updated: August 8, 2013
Last verified: August 2013
  Purpose

The researcher want to study compounds present in the skin, which may increase blood vessel formation. This is important because if certain compounds are increased in these skin lesions which help promote blood vessel formation and growth of skin lesions, these compounds may be the targets of future treatments. Future medications may be able to directly target these compounds in order to slow blood vessel formation and treat certain skin conditions.


Condition Intervention Phase
Dermatologic Diseases
Other: dermatologic diseases
Phase 1

Study Type: Interventional
Study Design: Endpoint Classification: Bio-availability Study
Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target

Resource links provided by NLM:


Further study details as provided by University of California, Irvine:

Primary Outcome Measures:
  • expression of various angiogenic factors in dermatologic diseases. [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 100
Study Start Date: November 2008
Estimated Study Completion Date: January 2015
Estimated Primary Completion Date: January 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
dermatologic diseases
dermatologic diseases
Other: dermatologic diseases
dermatologic diseases
Other Name: dermatologic diseases

Detailed Description:

Subjects who agree to participate will have one or more of their skin lesions biopsied. Such biopsies would be done the same way they would be done in clinic by your regular dermatologist. Additionally, normal skin biopsied as well so the researcher can compare normal skin to the skin lesion.

The biopsy specimen will be processed by doctors in the UC Irvine Dermatopathology Department and prepare the biopsy specimen for testing. The researcher want to do specific tests on the biopsy in order to study the compounds in the skin lesion.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18 years of age or older.
  • willing to have a skin biopsy

Exclusion Criteria:

  • under 18 years of age
  • unable to carry out instructions
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00842283

Contacts
Contact: Kristen Kelly, MD 949-824-7997 kmkelly@uci.edu
Contact: Montana Compton, RN 949-824-9265 mocomton@uci.edu

Locations
United States, California
Beckman Laser Institute Medical clinic Recruiting
Irvine, California, United States, 92612
Contact: Kristen Kelly, MD    949-824-7997    kmkelly@uci.edu   
Contact: Montana Compton, RN    949-824-9265    mocomton@uci.edu   
Principal Investigator: Kristen Kelly, MD         
Sub-Investigator: Montana Compton, RN         
Sub-Investigator: Larisa Lehmer, BS         
Sub-Investigator: Shaadi Khademi, MD         
Sponsors and Collaborators
Montana Compton
Beckman Laser Institute University of California Irvine
Investigators
Principal Investigator: Kristen Kelly, MD Beckman Laser Institute University of California Irvine
  More Information

No publications provided

Responsible Party: Montana Compton, Administrative Nurse Research Coordinator Beckman Laser Institute, University of California, Irvine
ClinicalTrials.gov Identifier: NCT00842283     History of Changes
Other Study ID Numbers: LAMMP-RR 01192
Study First Received: February 11, 2009
Last Updated: August 8, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, Irvine:
dermatologic diseases

Additional relevant MeSH terms:
Skin Diseases

ClinicalTrials.gov processed this record on April 14, 2014