Airway Responsiveness and Inflammation in Adolescent Elite Swimmers: a 3-Year Prospective Follow-up Study
Recruitment status was Recruiting
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Purpose
Previously the investigators have found that adolescent elite swimmers, who have been involved in competitive swimming for only a few years, have not developed respiratory symptoms, signs of airway inflammation or airway hyperresponsiveness exept for a slight increase in airway responsiveness to eucapnic voluntary hyperpnea. In the current study, the investigators will be doing a 3-year follow-up study on the swimmers studied previously.
| Condition |
|---|
|
Asthma |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Airway Responsiveness and Inflammation in Adolescent Elite Swimmers: a 3-Year Prospective Follow-up Study |
- Airway responsiveness to eucapnic voluntary hyperpnea and methacholine [ Time Frame: Three years ] [ Designated as safety issue: No ]
- Airway inflammation [ Time Frame: Three years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Blood (serum, whole blood) Exhaled breath condensate Induced sputum
| Estimated Enrollment: | 33 |
| Study Start Date: | February 2009 |
| Estimated Study Completion Date: | June 2010 |
| Estimated Primary Completion Date: | June 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
| Swimmers |
Detailed Description:
Even though studies suggest that elite sport can cause AHR and airway inflammation, more studies are needed to elucidate how and when AHR and airway inflammation develop; and there is a lack of follow-up studies. The present study will give us a chance to do a follow-up study to register changes in AHR and airway inflammation in athletes without any significant airway changes at baseline.
Eligibility| Ages Eligible for Study: | 15 Years to 19 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Participants were all elite swimmers and part of the Danish National Swimming Association's talent program for young swimmers at the baseline study.
Inclusion Criteria:
- Age 15-19 years
- Part of the Danish National Swimming Association's talent program for young swimmers at the baseline study
- Informed consent
Exclusion Criteria:
- Upper respiratory tract infection in the previous 4 weeks (visits will be postponed)
Contacts and Locations| Contact: Lars Pedersen, MD PhD | (+45) 35 31 30 69 | lars.pedersen@dadlnet.dk |
| Denmark | |
| Respiratory and Allergy Research Unit, Department of Respiratory Medicine L, Bispebjerg Hospital | Recruiting |
| Copenhagen, Denmark, 2400 | |
| Contact: Lars Pedersen, MD PhD (+45) 35 31 30 69 lars.pedersen@dadlnet.dk | |
| Principal Investigator: | Lars Pedersen, MD PhD | Respiratory and Allergy Research Unit, Bispebjerg Hospital |
More Information
Publications:
| Responsible Party: | Lars Pedersen (MD PhD), Respiratory and Allergy Research Unit, Bispebjerg Hospital, Copenhagen, Denmark |
| ClinicalTrials.gov Identifier: | NCT00841425 History of Changes |
| Other Study ID Numbers: | H-B-2009-012 |
| Study First Received: | February 10, 2009 |
| Last Updated: | February 23, 2009 |
| Health Authority: | Denmark: The Regional Committee on Biomedical Research Ethics Denmark: Danish Dataprotection Agency |
Additional relevant MeSH terms:
|
Asthma Inflammation Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases |
Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Pathologic Processes |
ClinicalTrials.gov processed this record on May 23, 2013