Stromal Gene Expression During Pulmonary Sarcoidosis
to determine the genetic pathways operating at the tissue level to cause granulomatous inflammation in the lungs and lymph nodes of patients with sarcoidosis. By so doing, we hope to identify unique genetic mechanisms which will aid in the diagnosis of sarcoidosis and will help us understand the pathogenesis of this poorly understood disease.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Stromal Gene Expression During Pulmonary Sarcoidosis|
- To Identify Gene Expression Patterns That Specifically Correlate With Active Pulmonary Sarcoidosis. [ Time Frame: end of study ] [ Designated as safety issue: No ]
- To Determine if Gene Expression Patterns Correlate With The Severity of Illness Of Sarcoidosis Patients [ Time Frame: end of study ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||April 2005|
|Estimated Study Completion Date:||February 2012|
|Estimated Primary Completion Date:||February 2012 (Final data collection date for primary outcome measure)|
sarcoidosis patients undergoing clinical bronchoscopy
to collect small sample of lung tissue recovered from a clinical procedure such as bronchoscopy, or a mediastinoscopy (a procedure in which a lighted instrument (mediastinoscope) is inserted through a neck incision to visually examine the structures in the top of the chest cavity and to take a sample (biopsy) of tissue.