Comparison of Clomiphene Citrate and Gonadotropins in Ovulation Induction Cycles (cc versus FSH)
This study has been completed.
Universitair Ziekenhuis Brussel
Information provided by (Responsible Party):
Blockeel Christophe, Universitair Ziekenhuis Brussel
First received: February 3, 2009
Last updated: March 27, 2012
Last verified: March 2012
The purpose of the present study is to analyse prospectively if highly purified hMG compared with increased dose of clomiphene citrate has different outcomes in folliculogenesis in ovulation induction cycles.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
|Official Title:||Among Non-IVF Patients Undergoing Ovulation Induction With Clomiphene Citrate (Clomid® 50 mg), Does Administration of an Increased Dose of Clomiphene Citrate (Clomid® 100 mg) Compared With Gonadotropins, Achieve Similar Rates of Folliculogenesis?|
Resource links provided by NLM:
U.S. FDA Resources
Further study details as provided by Universitair Ziekenhuis Brussel:
Primary Outcome Measures:
- folliculogenesis [ Time Frame: april 2009 ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- pregnancy rate [ Time Frame: april 2009 ] [ Designated as safety issue: No ]
|Study Start Date:||August 2008|
|Study Completion Date:||March 2012|
|Primary Completion Date:||March 2012 (Final data collection date for primary outcome measure)|
Placebo Comparator: A
Patients undergo a standard treatment with clomiphene citrate from day 3 until day 7 of the cycle at a dose of 50 mg daily. If no reaction on day 13 of the cycle, an increased dose of 100 mg of clomiphene citrate is administered from day 13 until day 17 of the cycle.
Drug: clomiphene citrate
Active Comparator: B
Patients undergo a standard treatment with clomiphene citrate from day 3 until day 7 of the cycle at a dose of 50 mg daily. If no reaction on day 13 of the cycle, gonadotropins (75IU) are administered from day 13 until day 17 of the cycle.
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