An Evaluation of the Causes of Anemia in Patients With Heart Failure (ANCHOR)
Anemia is frequent in patients with heart failure. Few studies have clearly addressed the causes of anemia in patients with HF. The purpose of this study is to evaluate differences in blood concentrations of various substances related to inflammation, oxidative stress, renal function and other processes between individuals with 1) heart failure and anemia, 2) heart failure without anemia and 3) patients with kidney disease without systolic heart failure. This study will help to better understand the reasons why some people with heart failure have anemia.
Chronic Renal Failure
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Anemia in Chronic Heart Failure: Etiology, Comparisons With Renal Disease, and Relationships With Biomarkers and Left Ventricular Remodeling.|
- TNF alpha concentrations [ Time Frame: Visit 2 (within 2 weeks of baseline visit) ] [ Designated as safety issue: No ]
- Various echocardiographic measurements, markers of inflammation, oxydative stress, neurohormonal activity and myocardial extracellular matrix turnover will be measured [ Time Frame: Visit 2 (within 2 weeks of baseline visit) ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Plasma and serum samples for analysis of biomarkers.
|Study Start Date:||January 2008|
|Primary Completion Date:||February 2010 (Final data collection date for primary outcome measure)|
Patients with anemia and systolic heart failure
Patients with systolic heart failure but without anemia
Patients with at least moderate chronic renal failure, with or without anemia and without systolic heart failure.