How Does 4 Weeks of Increased Fast Food Intake Affect Metabolism?
Objective: To study the effect of fast food-based hyper-alimentation on liver enzymes and hepatic triglyceride content (HTGC)and metabolism.
Design: Prospective interventional study with parallel control group. Setting University Hospital of Linköping, Sweden. Participants: 12 healthy men and six healthy women with a mean (SD) age of 26 (6.6) years and a matched control group.
Intervention: Subjects in the intervention group aimed for a body weight increase of 5-15% by eating at least two fast food-based meals a day with the goal to double the regular caloric intake in combination with adoption of a sedentary lifestyle for four weeks.
Main outcome measures: Weekly changes of serum aminotransferases and HTGC measured by proton nuclear magnetic resonance-spectroscopy at baseline and after the intervention.
|Study Design:||Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||How Does 4 Weeks of Increased Fast Food Intake Affect Metabolism?|
- weight gain [ Time Frame: 1 month ] [ Designated as safety issue: No ]
|Study Start Date:||April 2006|
|Study Completion Date:||January 2009|
|Primary Completion Date:||December 2007 (Final data collection date for primary outcome measure)|
Active Comparator: 1
Fast food intake, doubling of caloric intake, in combination with sedentary behavior (no exercise)
Procedure: Fast food arm
Doubling of regular caloric intake based on fast food, no exercise allowed
No Intervention: 2
Control group, parallel
Please refer to this study by its ClinicalTrials.gov identifier: NCT00826631
|University Hospital of Linkoping|
|Linkoping, Sweden, 58185|