Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery
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Purpose
Acute lung injury is a common complication of cardiac surgery with cardiopulmonary bypass, and it is significantly related to prolonged postoperative recovery, hospital stays and medical cost. Currently available predictors of acute lung injury after cardiac surgery are still limited within clinical data. Several genetic polymorphism of inflammatory mediators have been reported to be associated with severity of sepsis and ARDS, but the association of these inflammatory polymorphism and acute lung injury after cardiac surgery has never been reported. This study is performed to investigate the association of genetic polymorphisms including TNF -308A/G, IL-10 -1082A/G and IL-6 -572C/G and postoperative lung injury.
| Condition |
|---|
|
Acute Lung Injury |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Association Study of Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery With Cardiopulmonary Bypass |
- Acute lung injury after cardiac surgery with cardiopulmonary bypass [ Time Frame: 24h after surgery ] [ Designated as safety issue: Yes ]
- circulating level of CRP, TNF-alpha, IL-10, IL-6; APACHE Ⅱ score; postoperative kidney injury, duration of ventilation, ICU stay and hospitalization; death in 28 days [ Time Frame: 24h and 1 month after surgery ] [ Designated as safety issue: Yes ]
Biospecimen Retention: Samples With DNA
3ml blood before surgery, after surgery and 24h after surgery respectively
| Enrollment: | 107 |
| Study Start Date: | May 2008 |
| Study Completion Date: | January 2009 |
| Primary Completion Date: | November 2008 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
ALI
patients with acute lung injury at 24h after cardiac surgery
|
|
Control
patients without acute lung injury 24h after cardiac surgery
|
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Unrelated Chinese Han patients undergoing elective cardiac surgery with CPB
Inclusion Criteria:
- Chinese Han unrelated population
- adult patients
- undergoing elective cardiac surgery with CPB
Exclusion Criteria:
- malignant tumor
- autoimmune disease, immunodeficiency or immunosuppressive therapy
- chronic renal disease (glomerular filtration rate < 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification>A)
- COPD, tuberculosis or other chronic pulmonary diseases
- anemia with hemoglobin lower than 90mmHg
- bleeding disorders
- postoperative pericardial tamponade requiring re-operation
- postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.
Contacts and Locations More Information
Publications:
| Responsible Party: | Jia-feng Wang, M.D., Changhai Hospital |
| ClinicalTrials.gov Identifier: | NCT00826072 History of Changes |
| Other Study ID Numbers: | PCSP-inflammation |
| Study First Received: | January 20, 2009 |
| Last Updated: | May 2, 2013 |
| Health Authority: | China: Ethics Committee |
Keywords provided by Changhai Hospital:
|
Single Nucleotide Polymorphism cardiopulmonary bypass cardiac surgery |
Additional relevant MeSH terms:
|
Acute Lung Injury Respiratory Distress Syndrome, Adult Lung Injury Lung Diseases |
Respiratory Tract Diseases Respiration Disorders Thoracic Injuries Wounds and Injuries |
ClinicalTrials.gov processed this record on May 23, 2013