Fluorine-18-α-Methyltyrosine Positron Emission Tomography (18F-FMT PET) for Therapy Response in Lung Cancer

This study has been completed.
Sponsor:
Collaborator:
J~pharma
Information provided by:
Gunma University
ClinicalTrials.gov Identifier:
NCT00826033
First received: January 20, 2009
Last updated: NA
Last verified: January 2009
History: No changes posted
  Purpose

L-[3-18F]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for positron emission tomography (PET). The investigators evaluated the value of 18F-FMT PET for the assessment of therapy response in patients with lung cancer as compared with that of 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) PET.

The patients with lung cancer underwent PET studies with 18F-FDG and 18F-FMT before and after radio-/chemotherapy. The investigators used the ratio of the SUVmax of the mediastinal (N2) lymph node to the SUVmax of the primary tumor (N/P ratio ). All patients were divided into two groups of N/P ratio<1 and N/P ratio≥1, and the survival time was estimated by Kaplan-Meier method.


Condition
Non-Small Cell Lung Cancer

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Fluorine-18-α-Methyltyrosine Positron Emission Tomography to Measure Therapy

Resource links provided by NLM:


Further study details as provided by Gunma University:

Groups/Cohorts
Therapy monitoring

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

This study was conducted at the Gunma University Hospital.

Criteria

Inclusion Criteria:

  • primary lung cancer All patients received first-line chemotherapy

Exclusion Criteria:

  • Patients with diabetus mellitus
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00826033

Locations
Japan
Gunma University Graduate School of Medicine
Gunma, Japan, 371-8511
Sponsors and Collaborators
Gunma University
J~pharma
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00826033     History of Changes
Other Study ID Numbers: Mol Imaing 1
Study First Received: January 20, 2009
Last Updated: January 20, 2009
Health Authority: Japan: Ministry of Health, Labor and Welfare

Keywords provided by Gunma University:
Fluorine-18-α-methyltyrosine
Positron emission tomography
Lung cancer
chemotherapy
monitoring

Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms

ClinicalTrials.gov processed this record on September 18, 2014