Regulation of Hepatic Insulin Extraction (RHIE)
- This study is in the area of Type 2 diabetes and genetics
- Healthy Volunteers and those with mild type 2 diabetes may be eligible to participate
- This study is searching for genes that may affect the body's processing/digestion of glucose/sugar
|Study Design:||Time Perspective: Cross-Sectional|
|Official Title:||Regulation of Hepatic Insulin Extraction:Alterations of Insulin Secretion in Subjects With Genetic Variants That Determine Risk for Non-Insulin Dependant Diabetes Mellitus|
- Genes affecting the development of Type 2 diabetes will be identified [ Time Frame: 1 year ] [ Designated as safety issue: No ]
- Any differences between genetic groups in the metabolism of glucose/sugar will be studied to the extent that the data allow [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Samples are collected for Glucose & various human peptide measurements and DNA. As peptide assay evolves, specimens may be re-tested.
|Study Start Date:||October 2000|
|Estimated Study Completion Date:||June 2015|
|Estimated Primary Completion Date:||June 2015 (Final data collection date for primary outcome measure)|
This group is just entering the study and will need to be genotyped.
This group has been genotyped and has the gene undergoing study at that time.
This group has been genotyped and does not have the gene currently under study.
This study is looking at the genetic influences of type 2 diabetes. It also is investigating the various gastric hormones including but not limited to: insulin, C-peptide, GIP, GLP, & Xenin.
|Principal Investigator:||Kenneth S Polonsky, MD||Washington University School of Medicine|