The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response
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Purpose
There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress. The reduced ability to sustain heat stress - "heat intolerance" is also attributed to over-expression of inflammatory cytokines. Acclimation to heat improves human sustainability to heat and is a leading protective factor against heat stroke. The investigators hypothesize that the lower stress encountered during the process of acclimation to heat will be reflected by an over-ride in the expression of anti-inflammatory over the pro-inflammatory cytokines. This, in turn will attenuate the pathological cascade leading to heat stroke.
| Condition | Intervention |
|---|---|
|
"Exposure to Heat" |
Other: exposure to heat |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Single Blind (Investigator) Primary Purpose: Basic Science |
| Official Title: | The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response |
- Investigating the variability in the levels of different cytokine and the kinetics in cytokine levels during the process of acclimation to heat. [ Time Frame: 12 days ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 12 |
| Study Start Date: | January 2009 |
| Estimated Study Completion Date: | January 2010 |
| Estimated Primary Completion Date: | January 2010 (Final data collection date for primary outcome measure) |
-
Other: exposure to heat
Eligibility| Ages Eligible for Study: | 18 Years to 25 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- age:18-25
- medically screened (healthy)
Exclusion Criteria:
- BMI over 22 kg/m2
- systolic blood pressure over 120 mmHg
- any febrile illness during the last week preceding the study
- any skin disease
- diabetes
- any heart conditions.
Contacts and Locations| Israel | |
| Heller Institute of Medical Reachearch, Sheba Medical Center | |
| Tel Hashomer, Israel, 52621 | |
| Study Director: | Daniel S Moran, PhD | Institute of Military Physiology, IDF Medical Corps |
More Information
No publications provided
| Responsible Party: | Ypram Epstein, PhD; Head Physiology Department at the Heller Institute of Medical Resaearch, Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer |
| ClinicalTrials.gov Identifier: | NCT00808925 History of Changes |
| Other Study ID Numbers: | SHEBA-08-5524-YE-CTIL |
| Study First Received: | December 15, 2008 |
| Last Updated: | December 14, 2009 |
| Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
Keywords provided by Sheba Medical Center:
|
acclimation heat cytokines stress inflammation |
Additional relevant MeSH terms:
|
Anti-Inflammatory Agents Therapeutic Uses Pharmacologic Actions |
ClinicalTrials.gov processed this record on May 19, 2013