Functional Proteomics of Alveolar Macrophages
The purpose of this study is to obtain young white blood cells (monocytes) from the investigators donated blood for research into how these cells change into large, mature white blood cells (macrophages) and how smoking causes Chronic Obstructive Pulmonary Disease (COPD).
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Functional Proteomics of Alveolar Macrophages|
- to define AM's pathogenic pathways underlying the development of COPD [ Time Frame: end of study ] [ Designated as safety issue: No ]
- to determine protein polymorphism(s) that impact genetic susceptibility to COPD [ Time Frame: end of study ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
blood BAL fluid breathe condensation saliva
|Study Start Date:||July 2004|
|Study Completion Date:||December 2008|
|Primary Completion Date:||September 2008 (Final data collection date for primary outcome measure)|
Our research goal is to identify new targets and strategies to help care for patients with Chronic Obstructive Pulmonary Disease (COPD). COPD is a chronic airway inflammatory disorder characterized by a progressive loss of pulmonary function. Mononuclear phagocytes are known to be critically involved in both repair/remodeling and destructive events in COPD. Although smoking is the chief environmental risk factor for COPD, the molecular details responsible for the genesis and progression of smoking-mediated COPD require further investigation. In searching for new knowledge and research strategies for this challenging topic, we have made substantial progress in mononuclear phagocyte proteomics and laid the groundwork for this translational research of COPD.