Effect of Exercise on Heart Function in Healthy Elderly People

This study has been completed.
Sponsor:
Information provided by:
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT00804518
First received: December 8, 2008
Last updated: September 7, 2010
Last verified: September 2010
  Purpose

The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years. The old sedate cohort will be compared to young, sedate subjects also performing aerobic interval training and old master athletes without intervention.


Condition Intervention
Diastolic Dysfunction
Other: Aerobic interval training

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Aerobic Interval Training Reduces and Compensates Age Related Decline in Cardiac Function

Resource links provided by NLM:


Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Improvement of left and right ventricular early diastolic tissue velocity at rest and sub maximal exercise ,e'. [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Improvement of left and right ventricular systolic tissue velocity function at rest and sub maximal exercise, S'. [ Time Frame: 12weeks ] [ Designated as safety issue: No ]

Enrollment: 45
Study Start Date: November 2008
Study Completion Date: August 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise intervention Other: Aerobic interval training
High intensity aerobic interval training consists of 10 minutes warm up at ~60% of maximal heart rate, 4x4 minutes intervals at 90-95 % of maximal heart rate corresponding to 85-90% of VO2max) walking/running uphill on a treadmill, with three minutes active pause between the exercise bouts at 60-70% maximal heart rate. The session is terminated with 3 minutes cool down. Total exercise time is 38 minutes.The training is supervised by an exercise physiologist and the subjects train 3 times per week for 12 weeks.

Detailed Description:

Aging is associated with a reduced diastolic and systolic function of the heart. Earlier studies have shown that physical exercise can improve both systolic and diastolic function. However the impact on age-related cardiac function is to some extent conflicting. The use of different training intensities will impact on the cardiac result. We have in earlier studies shown aerobic interval training at 90 % of maximal heart rate (4x4 minutes) to have more impact on cardiac function, endothelial function and maximal oxygen uptake compared to moderate intensity.

To our knowledge the effect of aerobic interval training on cardiac function has not been studied in an old, sedate group before.

  Eligibility

Ages Eligible for Study:   70 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • over 70 years, healthy
  • not exercising more than twice per week

Exclusion Criteria:

  • chronic illness
  • chronic use of any medication
  • regular smoking
  • metabolic or cardiovascular diseases
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00804518

Locations
Norway
Ntnu/Dmf/Isb
Trondheim, Sør-Trøndelag, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Principal Investigator: Charlotte Bjork Ingul, PhD NTNU
  More Information

No publications provided

Responsible Party: post doctor Charlotte Bjork Ingul, Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00804518     History of Changes
Other Study ID Numbers: 4.2008.2177
Study First Received: December 8, 2008
Last Updated: September 7, 2010
Health Authority: Norway: Norwegian Social Science Data Services

Keywords provided by Norwegian University of Science and Technology:
Aging
Diastolic dysfunction
Systolic function
Exercise
Echocardiography
tissue Doppler imaging
Cardiac function

ClinicalTrials.gov processed this record on October 20, 2014