Serum Citrate in Diagnosis and Follow-up for Glaucoma

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by University Hospital, Basel, Switzerland.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Kantonsspital Baselland Bruderholz
Information provided by:
University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:
NCT00804063
First received: December 5, 2008
Last updated: June 7, 2011
Last verified: June 2011
  Purpose

Glaucoma might be a mitochondria associated disease. Since citrate is a major component in mitochondrial metabolism its determination in blood might serve as a biomarker.


Condition Intervention
Glaucoma
Procedure: drawing blood sample

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Serum Citrate in Diagnosis and Follow-up for Glaucoma

Resource links provided by NLM:


Further study details as provided by University Hospital, Basel, Switzerland:

Primary Outcome Measures:
  • serum citrate level [ Time Frame: 1 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • urine citrate [ Time Frame: 1 ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

blood, urine, serum, aqueous


Estimated Enrollment: 30
Study Start Date: December 2008
Estimated Study Completion Date: July 2013
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
glaucoma patients
Procedure: drawing blood sample
fasting blood sample
2
non-glaucoma controls
Procedure: drawing blood sample
fasting blood sample

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

tertiary university center

Criteria

Inclusion Criteria:

  • age> 18 years
  • glaucoma

Exclusion Criteria:

  • Active ocular inflammation
  • Ocular Hypertension
  • Nephropathy
  • Alcohol-, Drug abuse
  • Mitochondriopathy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00804063

Contacts
Contact: David Goldblum, MD +41 61 2652525 dgoldblum@uhbs.ch
Contact: Stephan Fraenkl, MD +41 61 2652525 fraenkls@uhbs.ch

Locations
Switzerland
University Hospital Basel Recruiting
Basel, BS, Switzerland, 4031
Contact: David Goldblum, MD    +41 61 2652525    dgoldblum@uhbs.ch   
Contact: Stephan Fraenkl, MD    +41 61 2652525    fraenkls@uhbs.ch   
Principal Investigator: David Goldblum, MD         
Sub-Investigator: Graziella Reinhard         
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Kantonsspital Baselland Bruderholz
Investigators
Principal Investigator: David Goldblum, MD University Hospital, Basel, Switzerland
Study Chair: Josef Flammer, MD University Hospital, Basel, Switzerland
Study Director: Selim Orguel, MD University Hospital, Basel, Switzerland
Principal Investigator: Stephan Fraenkl, MD University Hospital, Basel, Switzerland
Principal Investigator: Fabrizio Branca, MD University Basel
  More Information

No publications provided

Responsible Party: David Goldblum, MD, University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier: NCT00804063     History of Changes
Other Study ID Numbers: EK 325/08
Study First Received: December 5, 2008
Last Updated: June 7, 2011
Health Authority: Switzerland: Ethikkommission
Switzerland: Laws and standards

Keywords provided by University Hospital, Basel, Switzerland:
glaucoma
citrate

Additional relevant MeSH terms:
Glaucoma
Ocular Hypertension
Eye Diseases

ClinicalTrials.gov processed this record on August 19, 2014