Exercise Induced Asthma and Airway Reactivity in Athletes
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The overall aim is to explore pathophysiological factors related to airway hyperresponsiveness to direct and indirect provocation stimuli in athletes with different sport activities, with special focus on epithelial reaction linked to CC16 and to eicosanoid related inflammatory response. The investigators also wish to compare indirect testing done as hyper osmotic challenge with Mannitol compared to a defined sport specific exercise challenge.
| Condition |
|---|
|
Respiratory Function Tests |
| Study Type: | Observational |
| Study Design: | Time Perspective: Cross-Sectional |
| Official Title: | Explorative Study "Exercise Induced Asthma and Airway Reactivity in Athletes" |
| Enrollment: | 300 |
| Study Start Date: | March 2008 |
| Study Completion Date: | December 2009 |
By non-invasive tools the investigators wish to characterize type of airway reaction to various provocative stimuli in athletes doing two different sort activities, Tennis or swimming. As controls are being used sedentary age-matched controls from the same region, exposed to the same school environment. Thus we wish to:
- explore the prevalence of positive mannitol reactivity among swimmers and tennis player and how this relates to symptoms, disease history and to a sport specific exercise provocation test.
- compare the results from sport specific testing with a standardized eucapnic hyperventilation test (EHV)
- compare the overall reactivity to mannitol or EHV among swimmers and tennis players compared to aged matched controls.
- explore the role by CC16 in airway reactivity to different provocative stimuli and to see whether there is a difference between different sport activities, different test protocols and between athletes and controls.
- explore evidence of eicosanoid related inflammatory reaction in athletes and controls in relation to different provocative stimuli
The study population consists of 100 elite swimmers, 100 elite tennis players and 100 non-elite, eged matched controls. In the latter group, 30 are aged matched non-atopic non-asthmatic controls.
Eligibility| Ages Eligible for Study: | 16 Years to 25 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
100 elite swimmers 100 elite tennis players 100 aged matched non-atletic subjects, 30 aged-matcked healthy non-atopic controls
Inclusion Criteria:
- Subjects aged 16-19 from Skåne.
- All should approve attendance in the study by signing an informed consent. Igf they are aged under 18, parents should also sign.
- Three groups are included
- Elite aspiring swimmers with an average training intensity of at least hours per week the last year.
Exclusion Criteria:
Contacts and Locations More Information
No publications provided
| Responsible Party: | Professor Leif Bjermer, Lung and Alllergy research unit, Heart & Lung division, Lund University Hospital |
| ClinicalTrials.gov Identifier: | NCT00798564 History of Changes |
| Other Study ID Numbers: | 34797 |
| Study First Received: | November 25, 2008 |
| Last Updated: | August 2, 2011 |
| Health Authority: | Sweden: Regional Ethical Review Board |
Keywords provided by Skåne University Hospital:
|
Exercise Mannitol |
Additional relevant MeSH terms:
|
Asthma, Exercise-Induced Asthma Bronchial Diseases Respiratory Tract Diseases |
Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases |
ClinicalTrials.gov processed this record on May 22, 2013