Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy (EchoSpA)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2008 by Groupe Français d'Etude Génétique des Spondylarthropathies.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
French Society of Rheumatology
Information provided by:
Groupe Français d'Etude Génétique des Spondylarthropathies
ClinicalTrials.gov Identifier:
NCT00794404
First received: November 19, 2008
Last updated: NA
Last verified: November 2008
History: No changes posted
  Purpose

The purpose of this study is to evaluate the interest of enthesis sonography for the diagnosis of spondylarthritis, in patients with uncertain diagnosis consulting for clinical symptoms suggestive of spondylarthritis


Condition
Spondylarthropathy
Ankylosing Spondyloarthitis
Spondyloarthritis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy in Patients With Uncertain Diagnosis Consulting for Clinical Symptoms Suggestive of Spondylarthropathy

Resource links provided by NLM:


Further study details as provided by Groupe Français d'Etude Génétique des Spondylarthropathies:

Biospecimen Retention:   Samples With DNA

whole blood


Enrollment: 489
Study Start Date: January 2005
Estimated Study Completion Date: September 2009
Primary Completion Date: September 2007 (Final data collection date for primary outcome measure)
Detailed Description:

Spondylarthritis (SPA) are the second most frequent inflammatory rheumatic disorders and, because it starts early in life and has a chronic progressive course, the impact of this disease on health resources and patient's life quality can be important. Because the characteritic signs of SPA, like radiological evidence of sacro-iliitis, appear late in time, the lag time between the onset first signs of SPA for the patient and the confirmed diagnosis can be very long (up to 8 years). Previous studies proved that patients who are affected by SPA are showing abnormal vascularization of peripheral enthesis more frequently than patients affected by other rheumatic diseases. Ultrasonography in B mode combined with power Doppler (PDUS) is a non invasive and highly sensitive toll which can detect enthesitis and abnormal vsacularization even for the patients who are not showing yet the evidence of SPA's symptomatology. Using PDUS as a early diagnosis tool could lead to the improvement of diagnostic procedures and therapeutic management of SpA and reduce the cost of diagnosis for patient and health insurances.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with a symptomatology which can lead to a SPA diagnosis but with no confirmed diagnosis yet for any rheumatic didease.

Criteria

Inclusion Criteria:

  • patients < 50 years old, consulting for spinal inflammatory symptoms > 3 months duration
  • patients consulting for arthritis or tenderness joints > 3 months duration
  • patients < 50 years old consulting for enthesitis or dactylitis > 3 months duration
  • patients with uveitis and HLA-B27 positivity
  • relatives of SpA patients consulting for symptoms suggestive of SpA

Exclusion Criteria:

  • patient with confirmed diagnosis of rheumatic disease (included SpA)
  • patient protected by law (patient <18 years old, pregnant woman)
  • patient who can't atempt the RMI
  • patient who will have difficulties to complete the two years of follow-up
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00794404

Locations
France
Ambroise Paré Hospital
Boulogne Billancourt, France, 92100
Cavale Blanche Hospital
Brest, France, 29200
Cote de Nacre Hospital
Caen, France, 14033
South Hospital of Grenoble
Echirolles, France, 38434
Conception Hospital
Marseille, France, 13005
Nancy Brabois Hospital
VANDOEUVRE les NANCY, France, 54511
Sponsors and Collaborators
Groupe Français d'Etude Génétique des Spondylarthropathies
French Society of Rheumatology
Investigators
Principal Investigator: D'AGOSTINO Maria-Antonietta, MCUPH Ambroise Paré Hospital
  More Information

No publications provided by Groupe Français d'Etude Génétique des Spondylarthropathies

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: D'AGOSTINO Maria Antonietta, MCUPH, GESPA
ClinicalTrials.gov Identifier: NCT00794404     History of Changes
Other Study ID Numbers: GESPA
Study First Received: November 19, 2008
Last Updated: November 19, 2008
Health Authority: France: Ministry of Health

Additional relevant MeSH terms:
Spondylarthritis
Spondylarthropathies
Arthritis
Bone Diseases
Joint Diseases
Musculoskeletal Diseases
Spinal Diseases
Spondylitis

ClinicalTrials.gov processed this record on October 23, 2014