Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease (CKD)
The Diffuse Optical Spectroscopy (DOS) measure the absolute concentrations of reduced and oxygenated hemoglobins ([Hb-R] and [HbO2], respectively) as well as the water and lipid concentrations of the tissue.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Non-invasive Spectroscopic Measurements of the Concentrations of Blood, Water, and Lipids in Tissues|
- clinical parameters cause of chronic kidney disease [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]
|Study Start Date:||August 2008|
|Study Completion Date:||March 2012|
|Primary Completion Date:||March 2012 (Final data collection date for primary outcome measure)|
Device: Diffuse Optical Spectroscopy
DOS have been shown to correlate with invasive measures of cardiac output, mean arterial pressure, blood loss, and blood hemoglobin concentration.
The researchers want to use DOS as a means to monitor volume changes during the hemodialysis treatment and to correlate the changes in volume and blood pressure with the measures of oxidative stress and inflammation used in this study.
The researchers want compared to a variety of laboratory parameters routinely measured in CKD subjects (GFR, proteinuria, Hg, serum albumin, bicarbonate, calcium, phosphorous, iron saturation, ferritin, lipid profiles, PTH) and to clinical parameters such as cause of CKD, blood pressure and dialysis-related parameters.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00793806
|United States, California|
|Beckman Laser Institute|
|Irvine, California, United States, 92612|
|University of California Medical Center: Dialysis Unit|
|Orange, California, United States, 92868|
|UCIMC Dialysis center|
|Orange, California, United States, 92869|
|Principal Investigator:||Madeleine Pahl, M.D.||University of California, Irvine|