Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects
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Purpose
Increased intake of dietary fibre and whole grains is related to reduced risk of developing diabetes. The term "whole grain" is often used for whole-meal products in which the structure of the cereal grain is destroyed in the flour containing the original dietary fiber, but also for cereal products in which a large proportion of whole cereal grains is intact. The aim of this study was to evaluate the effect of commercial rye whole-meal bread (RWMB) compared to white-wheat bread (WWB) on gastric emptying rate (GER), postprandial glucose response in healthy subjects.
| Condition |
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Healthy |
| Study Type: | Observational |
| Official Title: | Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects |
| Groups/Cohorts |
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Healthy subjects
Healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus
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Detailed Description:
Ten healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus, were assessed by using a blinded crossover trial. The subjects were examined regarding blood glucose levels and GER after ingestion of 150g WWB or RWMB on two different occasions after an overnight fast. GER was measured using a standardized real time ultrasonography. GER was calculated as a percentage change in antral cross sectional area 15 and 90 minutes after the finished meal with WWB and RWMB. Finger-prick capillary samples were collected before and 40, 60, and 90 min after the start of the meal to measure blood glucose levels.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
All subjects were recruited from the population in a southern county of Sweden.
Inclusion Criteria:
- without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus
Exclusion Criteria:
- with symptoms or prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus
Contacts and Locations More Information
No publications provided by Lund University Hospital
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| ClinicalTrials.gov Identifier: | NCT00779298 History of Changes |
| Other Study ID Numbers: | Dnr 709/2004 |
| Study First Received: | October 22, 2008 |
| Last Updated: | October 23, 2008 |
| Health Authority: | Sweden: Regional Ethical Review Board |
Keywords provided by Lund University Hospital:
|
rye whole-meal bread white-wheat bread gastric emptying rate postprandial glucose response healthy subjects |
ClinicalTrials.gov processed this record on June 17, 2013