Identification of Novel Targets for Regulation of Adipose Tissue Mass
The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Identification of Novel Targets for Regulation of Adipose Tissue Mass|
- number of adipocytes and preadipocytes under weight loss [ Time Frame: three years ] [ Designated as safety issue: No ]
- metabolic function of adipocytes and preadipocytes under weight loss [ Time Frame: three years ] [ Designated as safety issue: No ]
|Study Start Date:||October 2008|
|Study Completion Date:||August 2011|
|Primary Completion Date:||August 2011 (Final data collection date for primary outcome measure)|
Patients included take part at a weight reduction program over one year.
Dietary Supplement: Optifast
Formula diet for twelve weeks combined with physical activity and behavioral therapy