Inter Individual Variation in Weight Loss Response to Exercise
The identification and characterization of individuals who vary in their response to exercise-induced weight loss is important. Weight loss in response to exercise is variable and it remains unknown who will succeed, why, and more importantly how to improve weight loss efficacy.
This study will examine changes in behavioural, metabolic, physiological and biochemical variables in response to a 12 week supervised exercise programme and evaluate their association with weight loss in overweight and obese sedentary individuals.
Our hypothesis is that changes in the plasma levels of appetite related hormones undermine the inter individual variation in weight loss in response to exercise.
This study will improve the understanding of variability to exercise-induced weight loss and allow more individually tailored and appropriate strategies for weight management programmes.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Identification and Characterization of Individual Variability in Exercise-induced Weight Loss: Biological and Behavioral Markers of Success.|
- Changes in fasting and postprandial plasma levels of appetite related hormones [ Time Frame: Baseline and after a 12 week exercise intervention ] [ Designated as safety issue: No ]
- Changes in body weight and body composition [ Time Frame: Baseline and after a 12-week exercise intervention ] [ Designated as safety issue: No ]
|Study Start Date:||April 2008|
|Study Completion Date:||December 2009|
|Primary Completion Date:||February 2009 (Final data collection date for primary outcome measure)|
12-week supervised exercise programme (5 times /week at 75% maximal Heart Rate)
Purpose - To identify predictors of weight loss in overweigh/obese volunteers following a 12 week supervised exercise programme, and to characterise the variability in weight loss response.
Method - Longitudinal study aiming to identify predictors of weight loss in response to a 12-week exercise programme in healthy overweight/obese volunteers.
Subjective and objective measures of appetite, cardiovascular fitness, anthropometry, body composition, resting metabolic rate (RMR), fat and carbohydrate oxidation in the fasting state will be measured at baseline, before participants enroll for the study and after the exercise intervention.
The preload/test-meal paradigm (using a high and low-energy preload: HEP vs LEP) will be used to assess short-term appetite control before and after the exercise intervention following a randomized single-blinded crossover design. Moreover, the long-term effects of exercise on cytokine plasma levels and fasting and postprandial levels of appetite related hormones/metabolites will also be assessed at baseline and end of the study. Participants will act as their own controls throughout the study.
|Norwegian University of Science and Technology|
|Trondheim, Norway, 7030|
|Principal Investigator:||Catia Martins, BSc, MSc, PhD||Norwegian University of Science and Technology|