Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2010 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00772252
First received: October 14, 2008
Last updated: June 28, 2010
Last verified: June 2010
  Purpose

Background: In patients undergoing hemodialysis or hemofiltration will suffer from the injury of reactive oxidative species. Oxidative stress will affect cell membrane, protein, and DNA. It will damage the cell and result in organ dysfunction. We believe that in patients, who have acute hepatic failure, undergoing plasma exchange or Molecular Absorbent Recirculating System for bridge therapy will suffer from the injury of reactive oxidative species, too. It will damage the kidney, lung, cerebral cortex, and other organs. It may result in death before the recovery of liver function or undergoing liver transplantation.

Aims: 1. Investigate the severity of oxidative stress and risk factors of high oxidative stress in acute hepatic failure patient undergoing plasma exchange or Molecular Absorbent Recirculating System. 2. Investigate the microcirculation status and risk factors in acute hepatic failure patient undergoing plasma exchange or Molecular Absorbent Recirculating System. 3. Study the relationship between oxidative stress and microcirculation status. 4. Study the correlation between oxidative stress and prognosis. 5. Study the correlation between microcirculation status and prognosis.


Condition Intervention
Liver Failure
Critical Care
Other: liver support treatment

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 80
Study Start Date: August 2008
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
patient with hepatic failure undergoing liver support treatment in surgical intensive care unit
Other: liver support treatment
plasma exchange for liver support treatment

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients require liver support treatment

Criteria

Inclusion Criteria:

  1. Age > 18 years old
  2. Patients with acute deterioration on Chronic liver failure, who required liver support treamtment
  3. Patients with acute liver failure due to acute hepatitis, who reauired liver support treatment
  4. Patients with acute liver dysfunction within 7 days after liver transplantation, who required liver support treatment

Exclusion Criteria:

  1. Age > 70 years old
  2. Cancer, not curable
  3. Patients who had used of antioxidant therapy within 24 hours before study
  4. Patients who had received hyperbaric oxygen therapy within 24 hours before study
  5. Patients who had received peroxide treatment within 24 hours before study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00772252

Contacts
Contact: Yu-Chang Yeh 0968661829 tonyyeh@ntuh.gov.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Yu-Chang Yeh, bachelor    886-9-68661829    tonyyeh@ntuh.gov.tw   
Principal Investigator: Yu-Chang Yeh, Bachelor         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Yu-Chang Yeh, Bacehlor Department of Anesthesiology, NTUH
  More Information

No publications provided

Responsible Party: Yu-Chang Yeh / Doctor, NTUH
ClinicalTrials.gov Identifier: NCT00772252     History of Changes
Other Study ID Numbers: 200806004R
Study First Received: October 14, 2008
Last Updated: June 28, 2010
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Liver support treatment

Additional relevant MeSH terms:
Liver Failure
Digestive System Diseases
Hepatic Insufficiency
Liver Diseases
Liver Extracts
Hematinics
Hematologic Agents
Pharmacologic Actions
Therapeutic Uses

ClinicalTrials.gov processed this record on October 23, 2014