Relationship Between Polymorphism of Heat Shock Protein 70 Gene and Hepatocellular Carcinoma (HSP70)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00769535
First received: February 26, 2008
Last updated: April 26, 2013
Last verified: April 2013
  Purpose

Polymorphisms of HSP70 and tumor necrosis factor-alpha promoter in patients with hepatocellular carcinoma, chronic liver disease and healthy controls will be measured by PCR-RFLP or direct sequencing. The clinical relevance of patients will be compared in those with polymorphism and those without.


Condition Intervention
Hepatocellular Carcinoma
Genetic: Polymorphisms of HSP70 and TNF promoter

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Relationship Between Polymorphism of Heat Shock Protein 70 Gene and Hepatocellular Carcinoma

Resource links provided by NLM:


Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • Clinical relevance [ Time Frame: year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Clinical relevance [ Time Frame: year ] [ Designated as safety issue: No ]

Enrollment: 600
Study Start Date: January 2006
Study Completion Date: June 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: HSP70 and TNF polymorphisms Genetic: Polymorphisms of HSP70 and TNF promoter
To assess the relationship between clinical relevance and polymorphisms of HSP70 and tumor necrosis factor-alpha with PCR_RFLP
Other Names:
  • polymorphism of HSP70
  • polymorphism of tumor necrosis factor-alpha promoter

Detailed Description:

Heat shock protein 70 (HSP 70) may be involved in various aspects of immune system including infection, autoimmunity, and tumor immunity. The relationship between HSP70 expression, disease activity and cancer prognosis varied according to type of cancer. The overexpression of HSP70 by tumor cells contributes to tumor behavior. HSP70 is present in normal and abnormal hepatocytes, and was reported to be over-expressed in both hepatoma cell lines and human hepatocellular carcinoma (HCC) tissue. Recent study indicated that HSP70 is a molecular marker during early hepatocarcinogenesis. It is also involved in anti-tumor immunity in HCC.We also investigate the polymorphism of tumor necrosis factor-alpha promoter, and correlated to clinical relevance.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • History proven HCC patients

Exclusion Criteria:

  • No-definite diagnosed patients
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00769535

Locations
Taiwan
Kaohsiung Medical University
Kaohsiung, Kaohsiun, Taiwan, 807
Kaohsiung Medical University
Kaohsiung, Taiwan, 807
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Investigators
Principal Investigator: Jung-Fa Tsai, M.D., Ph.D. Professor of Medicine
  More Information

No publications provided

Responsible Party: Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier: NCT00769535     History of Changes
Other Study ID Numbers: KMUH-IRB-930047
Study First Received: February 26, 2008
Last Updated: April 26, 2013
Health Authority: Taiwan: Department of Health

Keywords provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:
heat shock protein70
tumor necrosis factor-alpha promoter
polymorphism

Additional relevant MeSH terms:
Carcinoma
Shock
Carcinoma, Hepatocellular
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Pathologic Processes
Adenocarcinoma
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Liver Diseases

ClinicalTrials.gov processed this record on July 20, 2014