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| Sponsored by: |
Weill Medical College of Cornell University |
|---|---|
| Information provided by: | Weill Medical College of Cornell University |
| ClinicalTrials.gov Identifier: | NCT00767767 |
Purpose
People often develop fearful responses to things, but have no conscious control over the fear (e.g. phobias). This is a basic form of unconscious memory, called âââ€-¬Ã<Å"fear conditioningâââ€-‰"¢. Intravenous anesthetic drugs have remarkable effects on conscious memory, but it is unknown whether they have similar effects on these unconscious fear memories. To address this question, the investigators will study 90 healthy adult volunteer subjects. The subject is given a very low dose of an anesthetic drug intravenously (i.e. through the bloodstream). The dose is so low that the subject might not even be able tell if they are getting the drug. While they are receiving the drug, the subject will perform a series of memory tests and a fear conditioning experiment, which are set up like a very simple computer game. To create the âââ€-¬Ã<Å"fear responseâââ€-‰"¢, subjects will occasionally receive a mildly uncomfortable shock to their arm. The subject is able to determine the highest level of shock that they will receive.
The investigators are doing this study because the investigators wish to know exactly how the drugs affect the way people process fear and emotion. This knowledge might one day be used in the treatment of some psychiatric disorders.
| Condition | Intervention |
|---|---|
|
Phobias |
Drug: Propofol Drug: Placebo Drug: Thiopental Drug: Midazolam Drug: Dexmedetomidine |
| Study Type: | Interventional |
| Study Design: | Basic Science, Randomized, Single Blind (Subject), Placebo Control, Parallel Assignment, Pharmacodynamics Study |
| Official Title: | The Effect of Intravenous Anesthetics on Fear Learning and Memory |
| Estimated Enrollment: | 90 |
| Study Start Date: | October 2008 |
| Estimated Study Completion Date: | December 2009 |
| Estimated Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
1: Placebo Comparator
Saline Infusion.
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Drug: Placebo
IV Saline infusion for 2 hours.
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2: Active Comparator
Anesthetic Drug Infusion.
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Drug: Propofol
IV Propofol infusion for 2 hours.
Drug: Thiopental
IV Thiopental infusion for 2 hours.
Drug: Midazolam
IV Midazolam infusion for 2 hours.
Drug: Dexmedetomidine
IV Dexmedetomidine Infusion for 2 hours.
|
Eligibility| Ages Eligible for Study: | 18 Years to 50 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Jackie Bogan, B.A. | 212-746-9419 | jab2035@med.cornell.edu |
| United States, New York | |
| Weill Cornell Medical College/New York Presbyterian Hospital | Recruiting |
| New York, New York, United States, 10065 | |
| Contact: Jackie Bogan, B.A. 212-746-9419 jab2035@med.cornell.edu | |
| Principal Investigator: Kane Pryor, MD | |
| Principal Investigator: | Kane Pryor, MD | Weill Cornell Medical College |
More Information
| Responsible Party: | Weill Cornell Medical College ( Kane Pryor ) |
| Study ID Numbers: | 0710009434 |
| Study First Received: | October 3, 2008 |
| Last Updated: | October 6, 2008 |
| ClinicalTrials.gov Identifier: | NCT00767767 History of Changes |
| Health Authority: | United States: Food and Drug Administration |
|
To investigate the effects of anesthetic drugs on associative memory processes involving fear |
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Anesthetics, Intravenous Neurotransmitter Agents Adrenergic alpha-Agonists Tranquilizing Agents Adrenergic Agents Thiopental Adjuvants, Immunologic Psychotropic Drugs Anesthetics Central Nervous System Depressants Phobic Disorders |
Midazolam Adrenergic Agonists Analgesics, Non-Narcotic Anesthetics, General Hypnotics and Sedatives Anti-Anxiety Agents Peripheral Nervous System Agents Analgesics Dexmedetomidine Propofol Anticonvulsants |
|
Neurotransmitter Agents Adrenergic Agents Molecular Mechanisms of Pharmacological Action Thiopental GABA Modulators Physiological Effects of Drugs Psychotropic Drugs Anesthetics Adrenergic Agonists Sensory System Agents Therapeutic Uses Hypnotics and Sedatives Dexmedetomidine Analgesics Propofol |
Anesthetics, Intravenous Adrenergic alpha-Agonists Tranquilizing Agents Central Nervous System Depressants Midazolam Pharmacologic Actions Adjuvants, Anesthesia Anesthetics, General Analgesics, Non-Narcotic GABA Agents Anti-Anxiety Agents Peripheral Nervous System Agents Central Nervous System Agents Anticonvulsants |
