Effects of Calcium and Phytate on Zinc Absorption

This study has been completed.
Sponsor:
Information provided by:
USDA Grand Forks Human Nutrition Research Center
ClinicalTrials.gov Identifier:
NCT00754390
First received: September 16, 2008
Last updated: May 31, 2011
Last verified: May 2011
  Purpose

This study is determine the effects of dietary calcium and phytate on zinc absorption.


Condition Intervention
Dietary Zinc Absorption
Dietary Supplement: Moderate Calcium, Low phytate Diet
Dietary Supplement: Moderate Calcium, High Phytate Diet
Dietary Supplement: High Calcium, Low Phytate Diet
Dietary Supplement: High Calcium, High Phytate Diet

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Effects of Calcium and Phytate on Zinc Absorption

Resource links provided by NLM:


Further study details as provided by USDA Grand Forks Human Nutrition Research Center:

Primary Outcome Measures:
  • Zinc Absorption [ Time Frame: 16 weeks ] [ Designated as safety issue: No ]
    Retention of Zinc-65 was monitored for 28 days by whole body scintillation counting. The percentage of Zinc-65 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic retention plot of percent Zinc-65 retained versus time


Enrollment: 17
Study Start Date: November 2005
Study Completion Date: May 2006
Primary Completion Date: May 2006 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Overall Study
Participants consumed 4 experimental diets for 4 weeks each in randomized order
Dietary Supplement: Moderate Calcium, Low phytate Diet
Participants consumed diet containing 700 milligrams calcium and 440 milligrams of phytate for 4 weeks
Dietary Supplement: Moderate Calcium, High Phytate Diet
Participants consumed diet containing 700 milligrams calcium and 1800 milligrams of phytate for 4 weeks
Dietary Supplement: High Calcium, Low Phytate Diet
Participants consumed diet containing 1900 milligrams calcium and 440 milligrams of phytate for 4 weeks
Dietary Supplement: High Calcium, High Phytate Diet
Participants consumed diet containing 1900 milligrams calcium and 1800 milligrams of phytate for 4 weeks

Detailed Description:

Zinc absorption is tested from 2 days of consuming each of four diets with zinc-65 isotope, followed by retention monitoring in a whole body scintillation counter for 4 weeks. All four 4 experimental diets are tested with each subject, in randomized order, for a total of 16 weeks.

  Eligibility

Ages Eligible for Study:   21 Years to 50 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Average weight for height

Exclusion Criteria:

  • Medications other than birth control pills or hormone replacement therapy,
  • Pregnancy within last 6 months
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00754390

Locations
United States, North Dakota
United States Department of Agriculture Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States, 58202
Sponsors and Collaborators
USDA Beltsville Human Nutrition Research Center
Investigators
Principal Investigator: Janet R Hunt USDA Grand Forks Human Nutrition Research Center
  More Information

No publications provided

Responsible Party: Janet R Hunt, Research Nutritiontist, United States Department of Agriculture Grand Forks Human Nutrition Research Center
ClinicalTrials.gov Identifier: NCT00754390     History of Changes
Other Study ID Numbers: GFHNRC042
Study First Received: September 16, 2008
Results First Received: December 17, 2008
Last Updated: May 31, 2011
Health Authority: United States: Federal Government

Keywords provided by USDA Grand Forks Human Nutrition Research Center:
dietary zinc absorption
dietary phytic acid
dietary calcium

Additional relevant MeSH terms:
Calcium, Dietary
Bone Density Conservation Agents
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on August 20, 2014