Diagnosis of Exercise-Induced Bronchospasm (EIB) and Asthma in National Collegiate Athletic Association (NCAA) Division I Athletes

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2008 by University of Arizona.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
GlaxoSmithKline
Information provided by:
University of Arizona
ClinicalTrials.gov Identifier:
NCT00752167
First received: September 11, 2008
Last updated: September 12, 2008
Last verified: September 2008
  Purpose

We hypothesize that exercise-induced bronchospasm (EIB) at the NCAA Division I collegiate level is over diagnosed, while poorly controlled asthma resulting in exercise-related symptoms in this same population may be under diagnosed, being erroneously attributed to EIB. This project will test individuals self-identified as having exercise induced bronchospasm or asthma, as well as gender-matched controls from the same sport, with eucapnic voluntary hyperventilation to assess for the presence of EIB or asthma. By making the correct diagnosis, improved health outcomes may be achieved and athletic performance may be enhanced.


Condition
Exercise Induced Bronchospasm, Asthma

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Diagnosis of EIB and Asthma in NCAA Division I Athletes

Resource links provided by NLM:


Further study details as provided by University of Arizona:

Primary Outcome Measures:
  • Change in FEV1 following eucapnic voluntary hyperventilation [ Time Frame: 3-21 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Protection from fall in FEV1 following eucapnic voluntary hyperventilation by preadministration of albuterol [ Time Frame: 3-21 minutes ] [ Designated as safety issue: No ]

Estimated Enrollment: 75
Study Start Date: February 2007
Groups/Cohorts
Case
all Division I athletes, male and female, at the University of Arizona that are currently being treated for either EIB or asthma by review of preparticipation physical forms or identified by the medical staff
Control
control athletes (ie, not currently being treated for either EIB or asthma by review of preparticipation physical forms or identified by the medical staff and/or not currently using asthma medications) from the same sport

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

NCAA Varsity Division I athletes attending the University of Arizona

Criteria

Inclusion Criteria:

  • varsity athlete
  • ability and willingness to give written informed consent

Exclusion Criteria:

  • inability to give written informed consent
  • unwillingness to perform spirometry or eucapnic voluntary hyperventilation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00752167

Contacts
Contact: David Millward, MD 520-626-6363 millward@msu.edu
Contact: Mark A Brown, MD 520-626-7780 mabrown@arc.arizona.edu

Locations
United States, Arizona
University of Arizona Recruiting
Tucson, Arizona, United States, 85724
Contact: David Millward, MD    520-626-6363    millward@msu.edu   
Sub-Investigator: Mark A Brown, MD         
Principal Investigator: David Millward, MD         
Sub-Investigator: Stephen Paul, MD         
Sub-Investigator: Donald Porter, MD         
Sub-Investigator: Michael Stilson, MD         
Sponsors and Collaborators
University of Arizona
GlaxoSmithKline
  More Information

No publications provided

Responsible Party: David Millward, MD, University of Arizona
ClinicalTrials.gov Identifier: NCT00752167     History of Changes
Other Study ID Numbers: GSK 110189
Study First Received: September 11, 2008
Last Updated: September 12, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by University of Arizona:
exercise induced bronchospasm
asthma
athlete
sports
eucapnic voluntary hyperventilation
albuterol

Additional relevant MeSH terms:
Asthma
Asthma, Exercise-Induced
Bronchial Spasm
Bronchial Diseases
Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases
Lung Diseases
Lung Diseases, Obstructive
Respiratory Hypersensitivity
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on October 21, 2014