Experimental Dentifrice Remineralization/ Fluoride Uptake in an In Situ Model
During each of the four treatment periods, subjects wore partial dentures containing two partially demineralized enamel specimens for two weeks- 24 hours per day, except when brushing (twice daily) with test dentifrice. Following each treatment period, the enamel specimen chips were removed and analyzed using Surface MicroHardness and microdrill enamel biopsy technique.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind
Primary Purpose: Treatment
|Official Title:||Exploratory Evaluation of an Experimental Fluoride Dentifrice Formulation Using an In Situ Remineralization/Fluoride Uptake Model|
- To compare the remineralization potential and fluoride uptake of an experimental dentifrice formulation to placebo formulation.
- To generate learnings regarding the relative remineralization potential and fluoride uptake between the experimental test dentifrices, currently marketed and placebo controls
|Study Start Date:||September 2007|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00752089
|United States, Indiana|
|GSK Investigational Site|
|Indianapolis, Indiana, United States, 46202|
|Study Director:||GSK Clinical Trials, BSc, MSc, PhD, MRSC(CChem)||GlaxoSmithKline|