MRI Screening for Patients With Myelodysplastic Syndrome (MDS), Who Have Received Multiple Red Blood Cell Transfusions (T2*MRI)
Recruitment status was Recruiting
A known risk of red blood cell transfusions is that it puts excess iron into the patient's body. Researchers are continually seeking the most effective method of measuring iron concentration. The purpose of this study is to determine how much iron has been deposited in a patient's heart and liver as a result of having received red blood cell transfusions using magnetic resonance imaging (MRI).
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Screening
|Official Title:||T2* Cardiac MRI Screening of Highly Transfused Patients With Myelodysplastic Syndrome|
- To evaluate the incidence of clinically significant cardiac iron overload in heavily transfused MDS patients using T2* MRI. [ Time Frame: A single T2* MRI will be performed on eligible patients. ] [ Designated as safety issue: No ]
- Evaluate left ventricular ejection fraction as assessed by T2* MRI. [ Time Frame: A single T2* MRI will be performed on eligible patients. ] [ Designated as safety issue: No ]
- Evaluate liver iron concentration as assessed by R2* MRI [ Time Frame: A single T2* MRI will be performed on eligible patients. ] [ Designated as safety issue: No ]
|Study Start Date:||September 2008|
|Estimated Study Completion Date:||June 2011|
|Estimated Primary Completion Date:||January 2011 (Final data collection date for primary outcome measure)|
Patients who meet eligibility will be sent for radiographic imaging to include T2* cardiac and liver MRI to ascertain quantification of organ-specific iron concentrations as well as cardiac left ventricular ejection fraction.
Other: T2* Cardiac and Liver MRI
Patients will undergo an MRI of the heart and liver.
|Contact: Tania Curcio, R.N.||212-746-2571|
|United States, New York|
|Weill Medical College of Cornell University||Recruiting|
|New York, New York, United States, 10065|
|Contact: Tania Curcio, R.N. 212-746-2571|
|Principal Investigator: Eric Feldman, M.D.|
|Principal Investigator:||Eric Feldman, M.D.||Weill Medical College of Cornell University|