How Improvement in Control of Diabetes Influences the Production of a Hormone Produced in the Gut Which Improves the Release and Action of Insulin. (MSD-GLP1)
The study is aimed at Type 2 Diabetics who are taking Metformin, but whose Diabetes remains poorly controlled. There are two additional medications already in use, Glimepiride and Sitagliptin will be compared to assess levels of improvement in Diabetes control.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||Influence of Improving Glycaemic Control on Glucagon-Like-Peptide-1 Response to an Oral Glucose Load. Comparison of Sulphonylurea With DPP-4 Inhibition.|
- Comparison of GLP-1 response at baseline and after 3 months treatment of both groups. [ Time Frame: 2 years ] [ Designated as safety issue: No ]
|Study Start Date:||September 2008|
|Study Completion Date:||September 2010|
|Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
|Active Comparator: 1||
3mg oral tablet.
Other Name: Amaryl.
|Active Comparator: 2||
100mg oral tablet.
Other Name: Januvia.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00747383
|Royal Bournemouth Hospital|
|Bournemouth, Dorset, United Kingdom, BH7 7DW|
|Principal Investigator:||David Kerr||Royal Bournemouth Hospital.|
|Principal Investigator:||Joseph Begley||Royal Bournemouth Hospital|