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The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2008 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00745758
First received: August 31, 2008
Last updated: September 2, 2008
Last verified: September 2008
  Purpose

Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product).Depletion of NO synthase (19,20,21) was also noted after SAH.CSF is produced from choroid plexus in the ventricle. If the SAH is too dense, the blood in the subarachnoid space will not easy to be washed out.


Condition
Subarachnoid Hemorrhage
Vasospasm, Intracranial

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA

CSF


Estimated Enrollment: 20
Study Start Date: May 2008
Estimated Study Completion Date: September 2008
Detailed Description:

Cerebral vasospasm remains a significant source of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) after an aneurysmal rupture. Despite being a significant source of morbidity and mortality, death and disability from vasospasm have declined from approximately 35% in the early 1970's, to between 15% and 20% in the 1980's to <10% in the 1990's(1,2,3,4).Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product)(1,12,13). This mechanism appears to be a multifactorial process that involves the generation of free radicals, lipid peroxidation and activation of protein kinase C as well as phospholipase C and A2 with resultant accumulation of diacylglycerol and the release of endothelin-1(14,15,16,17,18). On the other hand, depletion of NO synthase (19,20,21) was also noted after SAH. Previous reports showed that shunting of CSF through a lumbar drain after an SAH markedly reduces the risk of clinically evident vasospasm and its sequelae, shortens hospital stay, and improves outcome. Its beneficial effects are probably mediated through the removal of spasmogens that exist in the CSF(22). In our preliminary data, we have demonstrated a case with severe vasospasm, CSF was collected both from EVD and lumbar drain. The ADMA level and amount of Nitrate was well correlate with vasospasm and the level was much higher in lumbar drain then EVD. So, we will compared the CSF from EVD and lumbar puncture to see which factor is correlate with vasospasm.

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patient of spontaneous SAH

Criteria

Inclusion Criteria:

  • Aneurysmal rupture with SAH

Exclusion Criteria:

  • Bleeding tendency,
  • Large ICH with impending herniation
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00745758

Contacts
Contact: Kuo-Chuan Wang, MD 886-223123456 ext 5077 wang081466@yahoo.com.tw

Locations
Taiwan
devision of neurosurgery, National taiwan university hospital Recruiting
Taipei, Taiwan, 112
Contact: Kuo-Chuan Wang, MD    886223123456    wang081466@yahoo.com.tw   
Principal Investigator: Kuo-Chuan Wang, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Kuo-Chuan Wang, MD NTUH
  More Information

No publications provided

Responsible Party: Kuo-Chuan Wang, Devision of neurosurgery
ClinicalTrials.gov Identifier: NCT00745758     History of Changes
Other Study ID Numbers: 200803080R
Study First Received: August 31, 2008
Last Updated: September 2, 2008
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
SAH, vasospasm, ADMA

Additional relevant MeSH terms:
Hemorrhage
Subarachnoid Hemorrhage
Vasospasm, Intracranial
Brain Diseases
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Intracranial Hemorrhages
Nervous System Diseases
Pathologic Processes
Vascular Diseases

ClinicalTrials.gov processed this record on November 25, 2014