Abdominal Computed Tomography and the Blood Reactive Oxygen Species Level

This study has been withdrawn prior to enrollment.
(because of the presence of unexpected administrative barrier to interfere the collection of case)
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00745641
First received: September 1, 2008
Last updated: August 5, 2009
Last verified: March 2009
  Purpose

The clinically widely used X-ray computed tomography examination has a low-grade radiation effect and recently has attracted much attention concerning the possible adverse effects of radiation on human body [ref. 1-5]. The radiation is harmful to human tissues and cells mainly because it can interact with water (which makes up to 80% of cells) to generate reactive oxygen species (ROS), especially the formation of hydroxyl radicals. So far as we can reach, there is no report concerning the relation between X-ray computed tomography examination and the blood ROS level. Therefore, we wish to conduct this study to clarify if the routinely applied abdominal X-ray computed tomography examination may induce a higher level of ROS in the peripheral blood.

Study subjects will be patients who are admitted to our hospital because of abdominal diseases that need to receive abdominal X-ray computed tomography examination for diagnosis. In total, sixty cases will be enrolled for the study. The formal consent will be delivered and explained to the patients and families several hours before the performance of abdominal X-ray computed tomography. The formal consent will be retrieved and then the peripheral blood will be sampled just before the performance of computed tomography.ROS level in the sampled peripheral blood, before and after the performance of abdominal X-ray computed tomography, will be measured, compared, and analyzed. Totally 120 blood samples, including 60 samples just before and 60 samples 2 hours after the performance of computed tomography, will be collected from 60 study subjects within 5 months (August 10 ~ December 30, 2008). Reactive oxygen species(ROS)levels will be measured by a chemiluminescence (CL) analysing system (CLD-110, Tohoku Electronic Industrial, Sendai, Japan).


Condition
Radiation Injury

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effect of Abdominal X-ray Computed Tomography Examination on the Blood Reactive Oxygen Species Level

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   None Retained

only peripheral blood will be collected for measurement of reactive oxygen species.


Estimated Enrollment: 60
Study Start Date: September 2008
Estimated Study Completion Date: December 2008
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Sixty patients with abdominal illness and scheduled abdominal X-ray computed tomography examination will be included.

  Eligibility

Ages Eligible for Study:   20 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patients with abdominal illness that needs a computed tomography examination

Criteria

Inclusion Criteria:

  • patients with abdominal illness that needs a computed tomography examination

Exclusion Criteria:

  • none
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00745641

Locations
Taiwan
NTUH
Taipei, Taiwan, 10002
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Zei-Shung Huang, MD, PhD NTUH
  More Information

No publications provided

Responsible Party: Zei-Shung Huang, associate professor, Department of Internal Medicine, NTUH, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00745641     History of Changes
Other Study ID Numbers: 200807056R
Study First Received: September 1, 2008
Last Updated: August 5, 2009
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
radiation injury
computed tomography
reactive oxygen species
free radicals

Additional relevant MeSH terms:
Radiation Injuries
Wounds and Injuries

ClinicalTrials.gov processed this record on April 15, 2014