Effect of Tai Chi Chuan on Autonomic Nervous Modulation in Aged Subjects
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Purpose
Since Tai Chi Chuan (TCC) training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and cytokines production in the aged subjects.
| Condition | Intervention |
|---|---|
|
Healthy Subjects |
Procedure: Tai Chi Cuan |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Effect of Tai Chi Chuan on Autonomic Nervous Modulation, Blood Lipid and Cytokines Production in Aged Subjects |
- TCC training for 3 months can improve the pulmonary function, glucose availability and lipid profile, and increase the cytokines production and vagal modulation in aged subjects. [ Time Frame: 3 months ] [ Designated as safety issue: No ]
- Other effects of TCC observed [ Time Frame: 3 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Blood sample obtained from each subject was withdrawn for the quantitative measurements of total cholesterol (TC), high-density lipoprotein--cholesterol (HDL-C), high-density lipoprotein--cholesterol (LDL-C), triglyceride (TG), fasting blood sugar (FBS), and uric acid (UA). The immunoenzymometric assays for the quantitative measurement of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the serum were also performed on the blood sample from each subject.
| Enrollment: | 50 |
| Study Start Date: | May 2002 |
| Study Completion Date: | March 2004 |
| Primary Completion Date: | May 2003 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
1
Subjects in this group received TCC training for 3 months
|
Procedure: Tai Chi Cuan
Tai Chi Cuan training for 3 months
Other Name: Yang's Tai Chi Cuan
|
|
2
Subjects in this group received no TCC training within 3 months
|
Detailed Description:
Tai Chi Chuan (TCC) is a traditional Oriental conditioning exercise or calisthenics that is believed by many people around the world to be good for the health. The frequently claimed reason for this merit of TCC is that it can improve the cardiopulmonary function and immunity of the subject who practice it continuously. TCC has been shown to delay the decline of aerobic power, improve the cardiopulmonary function, balance and strength of the subjects. One study has demonstrated that TCC could reduce tension, anxiety, and mood disturbance. However, few studies have examined the effect of TCC on the blood lipid profile and immunity of the TCC practitioners. Another study reported that 12-week programme of regular TCC exercise enhanced functional mobility, personal health expectations, and regulatory T cell function. It has also been shown that an appropriate combination of TCC exercise program with diabetic medication might improve both glucose metabolism and immunity in type 2 diabetic patients. Since TCC training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC may also have an effect on the blood lipid profile and immunity of the subjects. We hypothesize that TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and cytokines production in the aged subjects. Thus, the aim of this study was to examine whether or not TCC have these effects in the aged subjects.
Eligibility| Ages Eligible for Study: | 50 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Healthy aged subjects
Inclusion Criteria:
- All subjects included in this study had normal lifestyles, and were capable of daily activities without limitations.
Exclusion Criteria:
- Subjects who had major cardiopulmonary disease or were on regular medicine for diabetes mellitus, hypertension, renal or liver disease were not included in the study.
Contacts and Locations| Taiwan | |
| Taipei Veterans General Hospital | |
| Taipei, Taiwan, 112 | |
| Principal Investigator: | Cheng-Deng Kuo, MD,PhD | Taipei Veterans General Hospital,Taiwan |
More Information
Publications:
| Responsible Party: | Cho-yu Chan, MD, Taipei Veterans General Hospital |
| ClinicalTrials.gov Identifier: | NCT00745303 History of Changes |
| Other Study ID Numbers: | VGH91-365-1 |
| Study First Received: | September 1, 2008 |
| Last Updated: | September 1, 2008 |
| Health Authority: | Taiwan: Institutional Review Board |
Keywords provided by Taipei Veterans General Hospital,Taiwan:
|
Tai Chi Chuan; Lipid; Cytokine |
ClinicalTrials.gov processed this record on May 21, 2013