Impulsivity, Neural Deficits and Cocaine Addiction
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Purpose
The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making to relapse style.
| Condition |
|---|
|
Cocaine Dependence |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Impulsivity, Neural Deficits, and Relapse in Cocaine Addiction |
- Determine if the brain regions involved in inhibition and decision-making are altered in cocaine-addicted subjects compared to healthy controls. [ Time Frame: 2 weeks ] [ Designated as safety issue: No ]
- In cocaine-addicted subjects, determine if neural deficits during disinhibition or decision-making are related to relapse following treatment. [ Time Frame: 6 months ] [ Designated as safety issue: No ]
- Assess the predictive validity of self-report measures of impulsive relapse. [ Time Frame: 6 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
urine, blood, plasma, and erythrocytes
| Enrollment: | 90 |
| Study Start Date: | April 2007 |
| Study Completion Date: | September 2012 |
| Primary Completion Date: | March 2012 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
1
Patients with Cocaine Addiction
|
|
2
Healthy Control Volunteers
|
Detailed Description:
This study is designed to explore putative differences in impulsive behaviors and decision making in cocaine-addicted and healthy control subjects using functional magnetic resonance imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We predict that cocaine-addicted subjects will demonstrate neurocognitive and neural alterations in measures of impulsivity and decision-making when compared to healthy controls. That is, cocaine-addicted subjects will show both decreased activation and decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures associated with impulsivity and decision-making. Furthermore, neurocognitive and neural deficits associated with impulsivity and decision-making will be associated with each other and with measures indicative of an impulsive relapse and altered decision making.
Eligibility| Ages Eligible for Study: | 21 Years to 55 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Patients will be recruited from residential treatment programs at the VA North Texas Health Care System, Nexus Recovery Inc., and Homeward Bound Inc. Healthy controls will be recruited from the Greater Dallas community.
Inclusion Criteria:
- Cocaine-dependence (patient population) or no cocaine-dependence (control population).
Exclusion Criteria:
- Other medical or psychiatric disorders that may effect neural functioning.
- Medications that may effect neural functioning.
Contacts and Locations| United States, Texas | |
| UT Southwestern Medical Center at Dallas, Divison on Addictions | |
| Dallas, Texas, United States, 75390-8564 | |
| Principal Investigator: | Bryon Adinoff, MD | UT Southwestern Medical Center at Dallas |
More Information
Additional Information:
No publications provided
| Responsible Party: | Bryon H Adinoff, Professor, University of Texas Southwestern Medical Center |
| ClinicalTrials.gov Identifier: | NCT00744601 History of Changes |
| Other Study ID Numbers: | DA023203, 1RO1DA023203-01 |
| Study First Received: | June 19, 2008 |
| Last Updated: | December 31, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Texas Southwestern Medical Center:
|
impulsivity cocaine dependence relapse |
neuroimaging functional magnetic resonance imaging (fMRI) single photon emission computed tomography (SPECT) |
Additional relevant MeSH terms:
|
Impulsive Behavior Cocaine-Related Disorders Substance-Related Disorders Mental Disorders Cocaine Vasoconstrictor Agents Cardiovascular Agents Therapeutic Uses Pharmacologic Actions Dopamine Uptake Inhibitors Dopamine Agents |
Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Neurotransmitter Uptake Inhibitors Physiological Effects of Drugs Anesthetics, Local Anesthetics Central Nervous System Depressants Sensory System Agents Peripheral Nervous System Agents Central Nervous System Agents |
ClinicalTrials.gov processed this record on May 19, 2013