Prospective Comparison of Immunological Benefit of Laparoscopic Colectomy
This study aimed to clarify existence of immunological benefit of laparoscopic colon cancer surgery compared to open colon surgery.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Prospective Comparative Study of Immunological Benefit Between Laparoscopic Colectomy and Open Colectomy|
- Immune factors [ Time Frame: post OP 5th day ] [ Designated as safety issue: No ]
- Post-operative complications [ Time Frame: POD 7th days ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2006|
|Study Completion Date:||November 2007|
|Primary Completion Date:||November 2007 (Final data collection date for primary outcome measure)|
Open colorectal resection
Laparoscopic colorectal resection
Patients with clinical stage Ⅲ left colon and upper rectal cancer were prospectively assigned to undergo LC (n=35) or OC (n=39). Factors related to cellular immunity of host (total lymphocyte count, CD4 lymphocyte, CD8 lymphocyte, CD4/CD8 ratio, HLA-DR expression on monocyte (mHLA-DR)) were examined preoperatively, on the 1st day of operation (POD1) and the 5th day of operation (POD5).