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A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Anatoly Dr. Kreinin, Tirat Carmel Mental Health Center
ClinicalTrials.gov Identifier:
NCT00741299
First received: August 25, 2008
Last updated: July 25, 2012
Last verified: July 2012
History of Changes
  Purpose

The purpose of this study is to examine whether tobacco smoking is associated with bipolar affective disorder (severity of depressive and manic symptoms, presence of psychotic symptoms, history of a suicide attempts and other clinical features.)


Condition
Bipolar Disorder

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Association Between Tobacco Smoking and Bipolar Affective Disorder.Clinico-epidemiological, Cross-sectional, Retrospective Study.

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Tirat Carmel Mental Health Center:

Primary Outcome Measures:
  • Relationship between smoking and other factors including: bipolar subtype, current and past clinical status, illness severity,history of a suicide attempts, age of bipolar onset, gender, education, social class, economic status. [ Time Frame: One interview session ] [ Designated as safety issue: No ]

Enrollment: 100
Study Start Date: August 2007
Study Completion Date: September 2009
Primary Completion Date: July 2009 (Final data collection date for primary outcome measure)
Detailed Description:

An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Only a few small descriptive studies have examined the prevalence and correlates of tobacco use among bipolar patients with conflicting results. Patients who smoke score higher on rating scales for psychotic symptoms than their non-smoking peers. While the association of smoking with psychotic symptomatology in schizophrenia is established, such association according to bipolar affective disorder has been reported in a few studies and remains unclear. Also a few studies reported about association of smoking with depressive and manic symptoms, and with suicidal behavior in bipolar patients. Thus further investigation of these issues is warranted.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

The sample will consist of all patients ascertained in database of Tirat Carmel Mental Health Center and Psychiatric Outpatients Clinic, Rambam Medical Center

Criteria

Inclusion Criteria:

  • Age 18-65 male or female
  • DSM -IV criteria for bipolar I affective disorder
  • Ability and willingness to sign informed consent for participation in the study

Exclusion Criteria:

  • Unwillingness or inability to participate in the study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00741299

Locations
Israel
Tirat Carmel Mental Health Center
Tirat HaCarmel, Israel, 30200
Sponsors and Collaborators
Tirat Carmel Mental Health Center
Investigators
Principal Investigator: Anatoly Kreinin, MD, PHD B. Rappaport Faculty of Medicine, Technion, Haifa
Principal Investigator: Anatoly Kreinin, MD, PhD B. Rappaport Faculty of Medicine, Technion, Haifa
  More Information

No publications provided by Tirat Carmel Mental Health Center

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Anatoly Dr. Kreinin, Director of psychiatric department, Tirat Carmel Mental Health Center
ClinicalTrials.gov Identifier: NCT00741299     History of Changes
Other Study ID Numbers: GKN2007, GKN2007
Study First Received: August 25, 2008
Last Updated: July 25, 2012
Health Authority: Israel: Ministry of Health

Keywords provided by Tirat Carmel Mental Health Center:
bipolar affective disorder, Smoking

Additional relevant MeSH terms:
Bipolar Disorder
Smoking
Mood Disorders
 Affective Disorders, Psychotic
Mental Disorders
Habits

ClinicalTrials.gov processed this record on June 17, 2013