Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
The aim of the proposed research is to measure the effect of drug-induced sedation on the functional connectivity between brain regions as indicated by EEG signal transmission within the human brain. The results of this study will help to identify the neurophysiological correlates of changes in conscious experience that occur during drug-induced sedation.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study|
- Defining the neurophysiological conditions that are necessary for conscious experience. [ Time Frame: Immediate ] [ Designated as safety issue: Yes ]
- Understanding the neurophysiological correlates of conditions associated with restricted conscious experience such as sedation and anesthesia. [ Time Frame: Immediate ] [ Designated as safety issue: Yes ]
|Study Start Date:||July 2008|
|Study Completion Date:||March 2010|
|Primary Completion Date:||March 2010 (Final data collection date for primary outcome measure)|
In the proposed experiments cortical areas will be stimulated using low frequency, low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during wakefulness and during drug-induced responsive sedation and unresponsive sedation. Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the temporal and spatial characteristics of evoked responses and induced rhythms over the cortex.
|United States, Wisconsin|
|University of Wisconsin Hospital and Clinics|
|Madison, Wisconsin, United States, 53792|
|Principal Investigator:||Robert Pearce, MD, PhD||University of Wisconsin, Madison|