Clinical Trial of Electro-Acupuncture Preconditioning in Patients Underwent Heart Valve Replacement Surgery
The purpose of this study is to investigate the protective effect of electro-acupuncture preconditioning in patients underwent cardiac surgery.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Clinical Trial of The Myocardial Protective Effects of Repeated Electroacupuncture Preconditioning in Heart Valve Replacement Surgery|
- late loss [ Time Frame: 12 months ] [ Designated as safety issue: No ]
|Study Start Date:||January 2007|
|Estimated Study Completion Date:||December 2008|
|Primary Completion Date:||July 2008 (Final data collection date for primary outcome measure)|
electro-acupuncture preconditioning group
Device: Electro-acupuncture preconditioning
Heart valve replacement surgery has been proved to be an effective method in treating both regenerative and rheumatic valve disease. Current studies showed that cardiopulmonary bypass (CPB) and operation related myocardial injury, as indicated by the release of perioperative cardiac enzymes, is associated with worse patient morbidity and mortality after elective valve replacement surgery. Although the actual mechanism is still unclear, it has been shown that ischemic preconditioning is one potential strategy for reduction of myocardial injury in open heart surgery. Recently, Electro- acupuncture (EA) was proved to produced cerebral protective and antiarrhythmic effects by mimicking ischemic preconditioning. This study aims to assess whether electroacupuncture preconditioning is also effective in reducing myocardial injury in adults with acquired heart valve disease undergoing elective valve replacement surgery.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00732459
|Department of Anesthesiology of Xijing Hospital, Fourth Military Medical University|
|Xi'an, Shaanxi, China, 710032|
|Study Chair:||Lize Xiong, M.D.||Director of Department of Anasthesiology of Xijing Hospital, Fourth Military Medical University|