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Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates

This study has suspended participant recruitment.
(No funding)
Sponsor:
Information provided by (Responsible Party):
Karen Ordovas, University of California, San Francisco
ClinicalTrials.gov Identifier:
NCT00727051
First received: July 29, 2008
Last updated: August 15, 2014
Last verified: August 2014
  Purpose

The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for coronary artery disease in high risk patients prior to liver and lung transplantation. The current protocol for coronary artery disease assessment at UCSF before liver and lung transplantation involves screening with stress tests and/or coronary angiograms in patients with increased risk of coronary artery disease. Coronary angiogram will be used as gold standard for assessment of coronary CTA accuracy.


Condition
Coronary Artery Disease

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates.

Resource links provided by NLM:


Further study details as provided by University of California, San Francisco:

Primary Outcome Measures:
  • patients suspected of having coronary artery disease (CAD) [ Time Frame: 1-30 days before invasive coronary angiography is performed ] [ Designated as safety issue: No ]

Estimated Enrollment: 20
Study Start Date: June 2007
Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Liver and lung transplant candidates referred for coronary angiography will be invited to participate in the study.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Liver and lung transplant candidates referred for coronary angiography.

Criteria

Inclusion Criteria:

  1. Liver transplant candidates referred for invasive coronary angiography which include:

    • Patients with suspicious symptoms for CAD or;
    • Asymptomatic patients;
    • Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF < 60% on echo.
  2. Lung transplant candidates referred for invasive coronary angiography which include:

    • Patients with suspicious symptoms for CAD or;
    • Asymptomatic patients;
    • Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF < 60% on echo in patients with low SVR (typical for ESLD).
  3. Any ethnic background is acceptable.

Exclusion Criteria:

  1. Patients with contraindications for the use of iodinated contrast (allergic reaction, renal failure, multiple myeloma, etc) will be excluded.
  2. Children and pregnant women will be excluded because of risks associated with radiation exposure.
  3. Patients must have no atrial fibrillation, as this will interfere with cardiac gating for the examination.
  4. Patients unable to give informed consent will be excluded as well.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00727051

Locations
United States, California
UCSF Medical Center
San Francisco, California, United States, 94143
Sponsors and Collaborators
University of California, San Francisco
  More Information

Publications:

Responsible Party: Karen Ordovas, Associate Professor of Radiology, University of California, San Francisco
ClinicalTrials.gov Identifier: NCT00727051     History of Changes
Other Study ID Numbers: H9730-30837
Study First Received: July 29, 2008
Last Updated: August 15, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, San Francisco:
invasive coronary angiography
multidetector coronary CTA
coronary artery disease
detecting coronary artery disease

Additional relevant MeSH terms:
Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Arteriosclerosis
Cardiovascular Diseases
Heart Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on November 24, 2014