Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates
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Purpose
The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for coronary artery disease in high risk patients prior to liver and lung transplantation. The current protocol for coronary artery disease assessment at UCSF before liver and lung transplantation involves screening with stress tests and/or coronary angiograms in patients with increased risk of coronary artery disease. Coronary angiogram will be used as gold standard for assessment of coronary CTA accuracy.
| Condition |
|---|
|
Coronary Artery Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Cross-Sectional |
| Official Title: | Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates. |
- patients suspected of having coronary artery disease (CAD) [ Time Frame: 1-30 days before invasive coronary angiography is performed ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 20 |
| Study Start Date: | June 2007 |
| Estimated Primary Completion Date: | July 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
1
Liver and lung transplant candidates referred for coronary angiography will be invited to participate in the study.
|
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Liver and lung transplant candidates referred for coronary angiography.
Inclusion Criteria:
Liver transplant candidates referred for invasive coronary angiography which include:
- Patients with suspicious symptoms for CAD or;
- Asymptomatic patients;
- Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF < 60% on echo.
Lung transplant candidates referred for invasive coronary angiography which include:
- Patients with suspicious symptoms for CAD or;
- Asymptomatic patients;
- Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF < 60% on echo in patients with low SVR (typical for ESLD).
- Any ethnic background is acceptable.
Exclusion Criteria:
- Patients with contraindications for the use of iodinated contrast (allergic reaction, renal failure, multiple myeloma, etc) will be excluded.
- Children and pregnant women will be excluded because of risks associated with radiation exposure.
- Patients must have no atrial fibrillation, as this will interfere with cardiac gating for the examination.
- Patients unable to give informed consent will be excluded as well.
Contacts and Locations
More Information
Publications:
| Responsible Party: | Karen G. Ordovas, MD, UCSF Department of Radiology |
| ClinicalTrials.gov Identifier: | NCT00727051 History of Changes |
| Other Study ID Numbers: | H9730-30837 |
| Study First Received: | July 29, 2008 |
| Last Updated: | July 31, 2008 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of California, San Francisco:
|
invasive coronary angiography multidetector coronary CTA coronary artery disease detecting coronary artery disease |
Additional relevant MeSH terms:
|
Coronary Artery Disease Myocardial Ischemia Coronary Disease Heart Diseases |
Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases |
ClinicalTrials.gov processed this record on June 13, 2013