Inclusion Criteria:

• Capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent.

• Adequate hepatobiliary function as indicated by the following laboratory values:

  • SGOT/SGPT <=2.5 x upper limit of normal
  • Alkaline phosphatase <=2.5 x upper limit of normal
  • Serum bilirubin < 1.5 mg/dl
  • Adequate renal function as indicated by the following laboratory values:
  • Creatinine Clearance >50 ml/min
• Age >/=18 years
• Zebroid performance status </= 2 (See Appendix A)
• Life expectancy is not severely limited by concomitant illness (i.e. < 3months life expectancy from non-leukemic conditions).
• No evidence of chronic active hepatitis or cirrhosis.
• HIV-negative
• Male and female patients must use an effective contraceptive method during the study and for a minimum of 6 months after study treatment.
• Female patients of childbearing potential must have a negative serum pregnancy test within 2 weeks prior to enrollment.

Exclusion Criteria:

• Current concomitant chemotherapy, radiation therapy, or immunotherapy other than as specified in the protocol.
• Use of investigational agents within 30 days or any anticancer therapy within 2 weeks before study entry with the exception of hydroxyurea. The patient must have recovered from all acute non-hematologic toxicities from any previous .
• Have any other severe concurrent disease, or have a history of serious organ dysfunction or disease involving the heart, kidney, liver, or other organ system that may place the patient at undue risk to undergo treatment.
• Patients with a systemic fungal, bacterial, viral, or other infection not controlled (defined as exhibiting ongoing signs/symptoms related to the infection and without improvement, despite appropriate antibiotics or other treatment).
• Pregnant or lactating patients.
• Any significant concurrent disease, illness, or psychiatric disorder that would compromise patient safety or compliance, interfere with consent, study participation, follow up, or interpretation of study results.