Pharmacokinetics of Carnosine

This study has been completed.
Sponsor:
Information provided by:
Tufts University
ClinicalTrials.gov Identifier:
NCT00721708
First received: July 22, 2008
Last updated: December 14, 2009
Last verified: December 2009
  Purpose

The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.


Condition Intervention
Oxidative Stress
Dietary Supplement: pure carnosine
Other: Beef
Other: Chicken
Other: Chicken broth

Study Type: Interventional
Study Design: Endpoint Classification: Pharmacokinetics Study
Intervention Model: Crossover Assignment
Masking: Open Label
Official Title: Pharmacokinetics of Carnosine

Further study details as provided by Tufts University:

Primary Outcome Measures:
  • Plasma histidine-dipeptide [ Time Frame: 0, 30, 60, 100, 180, 240, & 300 min ] [ Designated as safety issue: No ]

Enrollment: 4
Study Start Date: April 2007
Study Completion Date: July 2008
Primary Completion Date: October 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Carnosine(450 mg)
Dietary Supplement: pure carnosine
one time dose of pure carnosine (450 mg)
Experimental: 2
Beef (150g)
Other: Beef
one time dose, 150 g of beef
Experimental: 3
chicken (150g)
Other: Chicken
One time dose, 150g of chicken breast
Experimental: 4
Chicken broth (obtained from 150 g of chicken breast)
Other: Chicken broth
one time dose of chicken broth obtained from 150g of chicken breast

  Eligibility

Ages Eligible for Study:   40 Years to 70 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy adult
  • normal hematological parameters, normal serum albumin, normal liver function, normal kidney function

Exclusion Criteria:

  • History of smoking or alcoholism
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00721708

Locations
United States, Massachusetts
Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111
Sponsors and Collaborators
Tufts University
Investigators
Principal Investigator: Kyung-Jin Yeum, Ph.D. Tufts Medical Center
  More Information

Publications:
Responsible Party: Kyung-Jin Yeum, Scientist, Tufts University
ClinicalTrials.gov Identifier: NCT00721708     History of Changes
Other Study ID Numbers: TMC/TUHS IRB 7737
Study First Received: July 22, 2008
Last Updated: December 14, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by Tufts University:
histidine dipeptides
carnosine
anserine

ClinicalTrials.gov processed this record on October 29, 2014