Pharmacokinetics of Carnosine
This study has been completed.
Sponsor:
Tufts University
Information provided by:
Tufts University
ClinicalTrials.gov Identifier:
NCT00721708
First received: July 22, 2008
Last updated: December 14, 2009
Last verified: December 2009
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Purpose
The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.
| Condition | Intervention |
|---|---|
|
Oxidative Stress |
Dietary Supplement: pure carnosine Other: Beef Other: Chicken Other: Chicken broth |
| Study Type: | Interventional |
| Study Design: | Endpoint Classification: Pharmacokinetics Study Intervention Model: Crossover Assignment Masking: Open Label |
| Official Title: | Pharmacokinetics of Carnosine |
Further study details as provided by Tufts University:
Primary Outcome Measures:
- Plasma histidine-dipeptide [ Time Frame: 0, 30, 60, 100, 180, 240, & 300 min ] [ Designated as safety issue: No ]
| Enrollment: | 4 |
| Study Start Date: | April 2007 |
| Study Completion Date: | July 2008 |
| Primary Completion Date: | October 2007 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
Carnosine(450 mg)
|
Dietary Supplement: pure carnosine
one time dose of pure carnosine (450 mg)
|
|
Experimental: 2
Beef (150g)
|
Other: Beef
one time dose, 150 g of beef
|
|
Experimental: 3
chicken (150g)
|
Other: Chicken
One time dose, 150g of chicken breast
|
|
Experimental: 4
Chicken broth (obtained from 150 g of chicken breast)
|
Other: Chicken broth
one time dose of chicken broth obtained from 150g of chicken breast
|
Eligibility| Ages Eligible for Study: | 40 Years to 70 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Healthy adult
- normal hematological parameters, normal serum albumin, normal liver function, normal kidney function
Exclusion Criteria:
- History of smoking or alcoholism
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00721708
Locations
| United States, Massachusetts | |
| Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University | |
| Boston, Massachusetts, United States, 02111 | |
Sponsors and Collaborators
Tufts University
Investigators
| Principal Investigator: | Kyung-Jin Yeum, Ph.D. | Tufts Medical Center |
More Information
Publications:
| Responsible Party: | Kyung-Jin Yeum, Scientist, Tufts University |
| ClinicalTrials.gov Identifier: | NCT00721708 History of Changes |
| Other Study ID Numbers: | TMC/TUHS IRB 7737 |
| Study First Received: | July 22, 2008 |
| Last Updated: | December 14, 2009 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Tufts University:
|
histidine dipeptides carnosine anserine |
ClinicalTrials.gov processed this record on May 23, 2013