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| Sponsor: | Henry Ford Health System |
|---|---|
| Information provided by: | Henry Ford Health System |
| ClinicalTrials.gov Identifier: | NCT00720980 |
Purpose
Granuloma annulare is a benign, usually self-limiting, cutaneous dermatosis, which typically presents as asymptomatic, flesh-colored or red papules, frequently arranged in an annular pattern on the distal extremities. Although localized granuloma annulare is most commonly observed, a generalized or disseminated form can occur. The etiology of granuloma annulare is unknown, however, multiple inciting factors have been proposed. The purpose of the investigators is to review the outcomes of treatment of granuloma annulare (GA) resistant to standard regimens that resolved after a 3-months treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy, successfully used to treat paucibacillary leprosy, a disease with clinical and histopathologic similarity to GA.
| Condition |
|---|
|
Granuloma Annulare |
| Study Type: | Observational |
| Study Design: | Case-Only, Retrospective |
| Official Title: | Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy |
| Enrollment: | 6 |
| Study Start Date: | May 2008 |
| Study Completion Date: | July 2008 |
| Primary Completion Date: | May 2008 (Final data collection date for primary outcome measure) |
We will document the regimen treatment each patient has had and then review the following from the patient's chart to target our specific aims as outlined above.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
The investigators reported 6 cases of resistant GA that resolved after a 3-month treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy. ROM therapy has been successfully used to treat patients with paucibacillary leprosy, which has morphologic and histologic similarities to GA.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, Michigan | |
| Henry Ford Medical Center | |
| Detroit, Michigan, United States, 48202 | |
| Principal Investigator: | Iltefat H Hamzavi, MD | Henry Ford Health System |
More Information
| Responsible Party: | Henry Ford Health System ( Iltefat H. Hamzavi, MD ) |
| Study ID Numbers: | IRB5074 |
| Study First Received: | July 21, 2008 |
| Last Updated: | July 21, 2008 |
| ClinicalTrials.gov Identifier: | NCT00720980 History of Changes |
| Health Authority: | United States: Institutional Review Board |
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granuloma annulare, ROM |
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Anti-Infective Agents Minocycline Molecular Mechanisms of Pharmacological Action Collagen Diseases Skin Diseases Ofloxacin Anti-Infective Agents, Urinary Enzyme Inhibitors Renal Agents Granuloma |
Pharmacologic Actions Lymphatic Diseases Anti-Bacterial Agents Pathologic Processes Therapeutic Uses Necrobiotic Disorders Connective Tissue Diseases Lymphoproliferative Disorders Nucleic Acid Synthesis Inhibitors Granuloma Annulare |