Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

This study has been completed.
Sponsor:
Information provided by:
Henry Ford Health System
ClinicalTrials.gov Identifier:
NCT00720980
First received: July 21, 2008
Last updated: NA
Last verified: May 2008
History: No changes posted
  Purpose

Granuloma annulare is a benign, usually self-limiting, cutaneous dermatosis, which typically presents as asymptomatic, flesh-colored or red papules, frequently arranged in an annular pattern on the distal extremities. Although localized granuloma annulare is most commonly observed, a generalized or disseminated form can occur. The etiology of granuloma annulare is unknown, however, multiple inciting factors have been proposed. The purpose of the investigators is to review the outcomes of treatment of granuloma annulare (GA) resistant to standard regimens that resolved after a 3-months treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy, successfully used to treat paucibacillary leprosy, a disease with clinical and histopathologic similarity to GA.


Condition
Granuloma Annulare

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

Resource links provided by NLM:


Further study details as provided by Henry Ford Health System:

Enrollment: 6
Study Start Date: May 2008
Study Completion Date: July 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Detailed Description:

We will document the regimen treatment each patient has had and then review the following from the patient's chart to target our specific aims as outlined above.

  1. What previous treatment options have been or/are currently being used?
  2. How long did the patient take the treatment for?
  3. Was the patient able to discontinue or become less dependent on prior treatment?
  4. Was the disease process slowed by the treatment?;
  5. Were there any side effects that the patient experienced with treatment?
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

The investigators reported 6 cases of resistant GA that resolved after a 3-month treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy. ROM therapy has been successfully used to treat patients with paucibacillary leprosy, which has morphologic and histologic similarities to GA.

Criteria

Inclusion Criteria:

  • Patients with granuloma annulare who are resistent to the standard treatment.

Exclusion Criteria:

  • Response to the standard treatment of granuloma annulare.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00720980

Locations
United States, Michigan
Henry Ford Medical Center
Detroit, Michigan, United States, 48202
Sponsors and Collaborators
Henry Ford Health System
Investigators
Principal Investigator: Iltefat H Hamzavi, MD Henry Ford Health System
  More Information

Publications:
Responsible Party: Iltefat H. Hamzavi, MD, Henry Ford Health System
ClinicalTrials.gov Identifier: NCT00720980     History of Changes
Other Study ID Numbers: IRB5074
Study First Received: July 21, 2008
Last Updated: July 21, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by Henry Ford Health System:
granuloma annulare, ROM

Additional relevant MeSH terms:
Granuloma
Granuloma Annulare
Lymphoproliferative Disorders
Lymphatic Diseases
Pathologic Processes
Necrobiotic Disorders
Collagen Diseases
Connective Tissue Diseases
Skin Diseases

ClinicalTrials.gov processed this record on September 29, 2014